|
Atomistry » Iodine » PDB 8e7f-8u90 » 8u2e | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Iodine » PDB 8e7f-8u90 » 8u2e » |
Iodine in PDB 8u2e: Bruton'S Tyrosine Kinase in Complex with N-[(2R)-1-[(3R)-3- (Methylcarbamoyl)-1H,2H,3H,4H,9H-Pyrido[3,4-B]Indol-2-Yl]-3-(3- Methylphenyl)-1-Oxopropan-2-Yl]-1H-Indazole-5-CarboxamideEnzymatic activity of Bruton'S Tyrosine Kinase in Complex with N-[(2R)-1-[(3R)-3- (Methylcarbamoyl)-1H,2H,3H,4H,9H-Pyrido[3,4-B]Indol-2-Yl]-3-(3- Methylphenyl)-1-Oxopropan-2-Yl]-1H-Indazole-5-Carboxamide
All present enzymatic activity of Bruton'S Tyrosine Kinase in Complex with N-[(2R)-1-[(3R)-3- (Methylcarbamoyl)-1H,2H,3H,4H,9H-Pyrido[3,4-B]Indol-2-Yl]-3-(3- Methylphenyl)-1-Oxopropan-2-Yl]-1H-Indazole-5-Carboxamide:
2.7.10.2; Protein crystallography data
The structure of Bruton'S Tyrosine Kinase in Complex with N-[(2R)-1-[(3R)-3- (Methylcarbamoyl)-1H,2H,3H,4H,9H-Pyrido[3,4-B]Indol-2-Yl]-3-(3- Methylphenyl)-1-Oxopropan-2-Yl]-1H-Indazole-5-Carboxamide, PDB code: 8u2e
was solved by
S.Gajewski,
M.C.Clifton,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 8u2e:
The structure of Bruton'S Tyrosine Kinase in Complex with N-[(2R)-1-[(3R)-3- (Methylcarbamoyl)-1H,2H,3H,4H,9H-Pyrido[3,4-B]Indol-2-Yl]-3-(3- Methylphenyl)-1-Oxopropan-2-Yl]-1H-Indazole-5-Carboxamide also contains other interesting chemical elements:
Iodine Binding Sites:
The binding sites of Iodine atom in the Bruton'S Tyrosine Kinase in Complex with N-[(2R)-1-[(3R)-3- (Methylcarbamoyl)-1H,2H,3H,4H,9H-Pyrido[3,4-B]Indol-2-Yl]-3-(3- Methylphenyl)-1-Oxopropan-2-Yl]-1H-Indazole-5-Carboxamide
(pdb code 8u2e). This binding sites where shown within
5.0 Angstroms radius around Iodine atom.
In total only one binding site of Iodine was determined in the Bruton'S Tyrosine Kinase in Complex with N-[(2R)-1-[(3R)-3- (Methylcarbamoyl)-1H,2H,3H,4H,9H-Pyrido[3,4-B]Indol-2-Yl]-3-(3- Methylphenyl)-1-Oxopropan-2-Yl]-1H-Indazole-5-Carboxamide, PDB code: 8u2e: Iodine binding site 1 out of 1 in 8u2eGo back to Iodine Binding Sites List in 8u2e
Iodine binding site 1 out
of 1 in the Bruton'S Tyrosine Kinase in Complex with N-[(2R)-1-[(3R)-3- (Methylcarbamoyl)-1H,2H,3H,4H,9H-Pyrido[3,4-B]Indol-2-Yl]-3-(3- Methylphenyl)-1-Oxopropan-2-Yl]-1H-Indazole-5-Carboxamide
Mono view Stereo pair view
Reference:
D.W.Robbins,
M.A.Noviski.
Discovery and Preclinical Pharmacology of Nx-2127, An Orally Bioavailable Degrader of Brutons Tyrosine Kinase with Immunomodulatory Activity For the Treatment of Patients with B Cell Malignancies To Be Published.
Page generated: Mon Aug 12 03:06:14 2024
|
Last articlesMg in 4Y52Mg in 4Y30 Mg in 4Y2V Mg in 4Y2X Mg in 4Y2Y Mg in 4Y2U Mg in 4Y2T Mg in 4Y2Q Mg in 4Y2R Mg in 4Y2S |
© Copyright 2008-2020 by atomistry.com | ||
Home | Site Map | Copyright | Contact us | Privacy |