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Iodine in PDB 1ecv: Crystal Structure of Protein Tyrosine Phosphatase 1B Complexed with 5- Iodo-2-(Oxalyl-Amino)-Benzoic Acid

Enzymatic activity of Crystal Structure of Protein Tyrosine Phosphatase 1B Complexed with 5- Iodo-2-(Oxalyl-Amino)-Benzoic Acid

All present enzymatic activity of Crystal Structure of Protein Tyrosine Phosphatase 1B Complexed with 5- Iodo-2-(Oxalyl-Amino)-Benzoic Acid:
3.1.3.48;

Protein crystallography data

The structure of Crystal Structure of Protein Tyrosine Phosphatase 1B Complexed with 5- Iodo-2-(Oxalyl-Amino)-Benzoic Acid, PDB code: 1ecv was solved by H.S.Andersen, L.F.Iversen, S.Branner, H.B.Rasmussen, N.P.H.Moller, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 6.00 / 1.95
Space group P 31 2 1
Cell size a, b, c (Å), α, β, γ (°) 87.870, 87.870, 103.120, 90.00, 90.00, 120.00
R / Rfree (%) 19.4 / 24.9

Iodine Binding Sites:

The binding sites of Iodine atom in the Crystal Structure of Protein Tyrosine Phosphatase 1B Complexed with 5- Iodo-2-(Oxalyl-Amino)-Benzoic Acid (pdb code 1ecv). This binding sites where shown within 5.0 Angstroms radius around Iodine atom.
In total only one binding site of Iodine was determined in the Crystal Structure of Protein Tyrosine Phosphatase 1B Complexed with 5- Iodo-2-(Oxalyl-Amino)-Benzoic Acid, PDB code: 1ecv:

Iodine binding site 1 out of 1 in 1ecv

Go back to Iodine Binding Sites List in 1ecv
Iodine binding site 1 out of 1 in the Crystal Structure of Protein Tyrosine Phosphatase 1B Complexed with 5- Iodo-2-(Oxalyl-Amino)-Benzoic Acid


Mono view


Stereo pair view

A full contact list of Iodine with other atoms in the I binding site number 1 of Crystal Structure of Protein Tyrosine Phosphatase 1B Complexed with 5- Iodo-2-(Oxalyl-Amino)-Benzoic Acid within 5.0Å range:
probe atom residue distance (Å) B Occ
A:I301

b:26.5
occ:1.00
 I19 A:878301 0.0 26.5 1.0
C6 A:878301 2.1 14.7 1.0
C5 A:878301 3.0 11.4 1.0
C1 A:878301 3.1 10.5 1.0
CG1 A:VAL49 4.0 14.3 1.0
CB A:TYR46 4.1 9.9 1.0
CD1 A:TYR46 4.1 11.8 1.0
CG A:TYR46 4.1 11.5 1.0
CH3 A:ACT302 4.2 22.1 1.0
C4 A:878301 4.3 12.0 1.0
C2 A:878301 4.4 7.4 1.0
O A:HOH364 4.5 29.7 1.0
CB A:ASP48 4.6 13.4 1.0
C3 A:878301 4.9 7.8 1.0
CE1 A:TYR46 4.9 12.6 1.0
CD2 A:TYR46 4.9 10.7 1.0

Reference:

H.S.Andersen, L.F.Iversen, C.B.Jeppesen, S.Branner, K.Norris, H.B.Rasmussen, K.B.Moller, N.P.Moller. 2-(Oxalylamino)-Benzoic Acid Is A General, Competitive Inhibitor of Protein-Tyrosine Phosphatases. J.Biol.Chem. V. 275 7101 2000.
ISSN: ISSN 0021-9258
PubMed: 10702277
DOI: 10.1074/JBC.275.10.7101
Page generated: Sun Aug 11 09:34:19 2024

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