Iodine in PDB 1etb: The X-Ray Crystal Structure Refinements of Normal Human Transthyretin and the Amyloidogenic Val 30-->Met Variant to 1.7 Angstroms Resolution

The structure of The X-Ray Crystal Structure Refinements of Normal Human Transthyretin and the Amyloidogenic Val 30-->Met Variant to 1.7 Angstroms Resolution, PDB code: 1etb was solved by B.C.Braden, L.K.Steinrauf, J.A.Hamilton, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	5.00 / 1.70
Space group	P 21 21 2
Cell size a, b, c (Å), α, β, γ (°)	43.720, 86.090, 65.790, 90.00, 90.00, 90.00
R / Rfree (%)	n/a / n/a

The binding sites of Iodine atom in the The X-Ray Crystal Structure Refinements of Normal Human Transthyretin and the Amyloidogenic Val 30-->Met Variant to 1.7 Angstroms Resolution (pdb code 1etb). This binding sites where shown within 5.0 Angstroms radius around Iodine atom.
In total 8 binding sites of Iodine where determined in the The X-Ray Crystal Structure Refinements of Normal Human Transthyretin and the Amyloidogenic Val 30-->Met Variant to 1.7 Angstroms Resolution, PDB code: 1etb:
Jump to Iodine binding site number: 1; 2; 3; 4; 5; 6; 7; 8;

Iodine binding site 1 out of 8 in the The X-Ray Crystal Structure Refinements of Normal Human Transthyretin and the Amyloidogenic Val 30-->Met Variant to 1.7 Angstroms Resolution


Mono view


Stereo pair view

A full contact list of Iodine with other atoms in the I binding site number 1 of The X-Ray Crystal Structure Refinements of Normal Human Transthyretin and the Amyloidogenic Val 30-->Met Variant to 1.7 Angstroms Resolution within 5.0Å range: probe atom residue distance (Å) B Occ 1:I128 b:28.8 occ:0.25 I3 1:T44128 0.0 28.8 0.2 C3 1:T44128 2.0 30.0 0.2 C2 1:T44128 2.9 30.0 0.2 C4 1:T44128 3.0 30.0 0.2 O4 1:T44128 3.3 30.0 0.2 C1' 1:T44128 4.0 30.0 0.2 C5 1:T44128 4.2 30.0 0.2 C1 1:T44128 4.2 30.0 0.2 C6' 1:T44128 4.4 30.0 0.2 CE 1:LYS15 4.4 21.9 0.8 CD1 1:LEU17 4.7 18.6 1.0 C6 1:T44128 4.7 30.0 0.2 C2' 1:T44128 4.8 30.0 0.2 NZ 1:LYS15 4.9 22.3 0.5 CD 1:LYS15 5.0 21.4 0.8 O 1:HOH217 5.0 31.8 0.3

Iodine binding site 2 out of 8 in the The X-Ray Crystal Structure Refinements of Normal Human Transthyretin and the Amyloidogenic Val 30-->Met Variant to 1.7 Angstroms Resolution


Mono view


Stereo pair view

A full contact list of Iodine with other atoms in the I binding site number 2 of The X-Ray Crystal Structure Refinements of Normal Human Transthyretin and the Amyloidogenic Val 30-->Met Variant to 1.7 Angstroms Resolution within 5.0Å range: probe atom residue distance (Å) B Occ 1:I128 b:35.0 occ:0.25 I3' 1:T44128 0.0 35.0 0.2 C3' 1:T44128 2.1 30.0 0.2 C4' 1:T44128 3.0 30.0 0.2 C2' 1:T44128 3.1 30.0 0.2 O4' 1:T44128 3.2 30.0 0.2 O 1:HOH216 4.0 38.0 0.2 C5' 1:T44128 4.3 30.0 0.2 C1' 1:T44128 4.4 30.0 0.2 C6' 1:T44128 4.8 30.0 0.2

Iodine binding site 3 out of 8 in the The X-Ray Crystal Structure Refinements of Normal Human Transthyretin and the Amyloidogenic Val 30-->Met Variant to 1.7 Angstroms Resolution


Mono view


Stereo pair view

A full contact list of Iodine with other atoms in the I binding site number 3 of The X-Ray Crystal Structure Refinements of Normal Human Transthyretin and the Amyloidogenic Val 30-->Met Variant to 1.7 Angstroms Resolution within 5.0Å range: probe atom residue distance (Å) B Occ 1:I128 b:30.5 occ:0.25 I5 1:T44128 0.0 30.5 0.2 C5 1:T44128 2.0 30.0 0.2 C6 1:T44128 2.9 30.0 0.2 C4 1:T44128 3.0 30.0 0.2 O4 1:T44128 3.2 30.0 0.2 C1' 1:T44128 3.8 30.0 0.2 CB 1:ALA108 4.0 17.1 1.0 C6' 1:T44128 4.1 30.0 0.2 C3 1:T44128 4.2 30.0 0.2 CG2 1:VAL121 4.2 21.5 1.0 C1 1:T44128 4.3 30.0 0.2 CG2 1:THR106 4.3 20.6 1.0 C2 1:T44128 4.7 30.0 0.2 C2' 1:T44128 4.8 30.0 0.2

Iodine binding site 4 out of 8 in the The X-Ray Crystal Structure Refinements of Normal Human Transthyretin and the Amyloidogenic Val 30-->Met Variant to 1.7 Angstroms Resolution


Mono view


Stereo pair view

A full contact list of Iodine with other atoms in the I binding site number 4 of The X-Ray Crystal Structure Refinements of Normal Human Transthyretin and the Amyloidogenic Val 30-->Met Variant to 1.7 Angstroms Resolution within 5.0Å range: probe atom residue distance (Å) B Occ 1:I128 b:18.3 occ:0.25 I5' 1:T44128 0.0 18.3 0.2 C5' 1:T44128 2.1 30.0 0.2 C6' 1:T44128 2.9 30.0 0.2 C4' 1:T44128 3.1 30.0 0.2 O 1:THR109 3.3 16.9 1.0 O4' 1:T44128 3.3 30.0 0.2 C 1:THR109 3.6 16.9 1.0 N 1:THR109 3.6 16.7 1.0 CG 1:LEU17 3.6 17.4 1.0 CD1 1:LEU17 3.7 18.6 1.0 CB 1:ALA108 3.9 17.1 1.0 CB 1:LEU17 3.9 17.8 1.0 C 1:ALA108 4.0 17.1 1.0 N 1:LEU110 4.0 16.7 1.0 CA 1:THR109 4.1 16.9 1.0 O 1:LYS15 4.1 17.2 1.0 N 1:LEU17 4.2 16.2 1.0 CA 1:ALA108 4.2 16.5 1.0 C1' 1:T44128 4.3 30.0 0.2 C3' 1:T44128 4.3 30.0 0.2 CA 1:LEU110 4.4 16.7 1.0 CB 1:LEU110 4.5 16.6 1.0 CG 1:LYS15 4.7 21.1 1.0 O 1:ALA108 4.7 16.7 1.0 O 1:HOH215 4.7 27.6 0.8 C 1:LYS15 4.7 16.9 1.0 CA 1:LEU17 4.8 16.4 1.0 C2' 1:T44128 4.8 30.0 0.2 C 1:VAL16 4.8 16.8 1.0 CA 1:VAL16 4.9 16.5 1.0

Iodine binding site 5 out of 8 in the The X-Ray Crystal Structure Refinements of Normal Human Transthyretin and the Amyloidogenic Val 30-->Met Variant to 1.7 Angstroms Resolution


Mono view


Stereo pair view

A full contact list of Iodine with other atoms in the I binding site number 5 of The X-Ray Crystal Structure Refinements of Normal Human Transthyretin and the Amyloidogenic Val 30-->Met Variant to 1.7 Angstroms Resolution within 5.0Å range: probe atom residue distance (Å) B Occ 2:I129 b:32.6 occ:0.25 I3 2:T44129 0.0 32.6 0.2 C3 2:T44129 2.0 30.0 0.2 C2 2:T44129 2.9 30.0 0.2 C4 2:T44129 3.0 30.0 0.2 O4 2:T44129 3.3 30.0 0.2 C1' 2:T44129 3.6 30.0 0.2 CD1 2:LEU17 3.6 23.2 1.0 C6' 2:T44129 3.9 30.0 0.2 C1 2:T44129 4.2 30.0 0.2 C5 2:T44129 4.2 30.0 0.2 C2' 2:T44129 4.3 30.0 0.2 CE 2:LYS15 4.4 24.0 0.8 CD2 2:LEU17 4.7 22.1 1.0 C6 2:T44129 4.7 30.0 0.2 CG 2:LEU17 4.7 20.9 1.0 C5' 2:T44129 4.8 30.0 0.2

Iodine binding site 6 out of 8 in the The X-Ray Crystal Structure Refinements of Normal Human Transthyretin and the Amyloidogenic Val 30-->Met Variant to 1.7 Angstroms Resolution


Mono view


Stereo pair view

A full contact list of Iodine with other atoms in the I binding site number 6 of The X-Ray Crystal Structure Refinements of Normal Human Transthyretin and the Amyloidogenic Val 30-->Met Variant to 1.7 Angstroms Resolution within 5.0Å range: probe atom residue distance (Å) B Occ 2:I129 b:26.8 occ:0.25 I3' 2:T44129 0.0 26.8 0.2 C3' 2:T44129 2.1 30.0 0.2 C4' 2:T44129 3.0 30.0 0.2 C2' 2:T44129 3.0 30.0 0.2 O4' 2:T44129 3.2 30.0 0.2 O 2:HOH212 3.8 38.1 0.2 C5' 2:T44129 4.3 30.0 0.2 C1' 2:T44129 4.3 30.0 0.2 C6' 2:T44129 4.8 30.0 0.2

Iodine binding site 7 out of 8 in the The X-Ray Crystal Structure Refinements of Normal Human Transthyretin and the Amyloidogenic Val 30-->Met Variant to 1.7 Angstroms Resolution


Mono view


Stereo pair view

A full contact list of Iodine with other atoms in the I binding site number 7 of The X-Ray Crystal Structure Refinements of Normal Human Transthyretin and the Amyloidogenic Val 30-->Met Variant to 1.7 Angstroms Resolution within 5.0Å range: probe atom residue distance (Å) B Occ 2:I129 b:28.8 occ:0.25 I5 2:T44129 0.0 28.8 0.2 C5 2:T44129 2.0 30.0 0.2 C6 2:T44129 2.9 30.0 0.2 C4 2:T44129 3.0 30.0 0.2 O4 2:T44129 3.2 30.0 0.2 CG2 2:THR106 4.0 23.6 1.0 C1' 2:T44129 4.0 30.0 0.2 C3 2:T44129 4.2 30.0 0.2 C6' 2:T44129 4.2 30.0 0.2 C1 2:T44129 4.3 30.0 0.2 CB 2:ALA108 4.3 20.3 1.0 C2 2:T44129 4.7 30.0 0.2 CD 2:LYS15 4.7 23.6 0.8 CG2 2:VAL121 4.8 26.0 1.0 CB 2:THR106 4.9 23.7 1.0

Iodine binding site 8 out of 8 in the The X-Ray Crystal Structure Refinements of Normal Human Transthyretin and the Amyloidogenic Val 30-->Met Variant to 1.7 Angstroms Resolution


Mono view


Stereo pair view

A full contact list of Iodine with other atoms in the I binding site number 8 of The X-Ray Crystal Structure Refinements of Normal Human Transthyretin and the Amyloidogenic Val 30-->Met Variant to 1.7 Angstroms Resolution within 5.0Å range: probe atom residue distance (Å) B Occ 2:I129 b:22.9 occ:0.25 I5' 2:T44129 0.0 22.9 0.2 C5' 2:T44129 2.0 30.0 0.2 C6' 2:T44129 2.9 30.0 0.2 C4' 2:T44129 3.0 30.0 0.2 O4' 2:T44129 3.2 30.0 0.2 O 2:THR109 3.2 17.1 1.0 CD1 2:LEU17 3.5 23.2 1.0 N 2:THR109 3.5 18.1 1.0 C 2:THR109 3.5 17.4 1.0 CG 2:LEU17 3.5 20.9 1.0 CB 2:ALA108 3.8 20.3 1.0 C 2:ALA108 3.9 18.8 1.0 CB 2:LEU17 3.9 20.2 1.0 N 2:LEU110 4.0 16.2 1.0 CA 2:THR109 4.1 17.5 1.0 CA 2:ALA108 4.2 19.0 1.0 C1' 2:T44129 4.2 30.0 0.2 C3' 2:T44129 4.3 30.0 0.2 N 2:LEU17 4.3 19.1 1.0 O 2:LYS15 4.3 21.0 1.0 CA 2:LEU110 4.3 16.1 1.0 CB 2:LEU110 4.4 17.4 1.0 O 2:HOH211 4.5 33.3 0.5 O 2:ALA108 4.6 18.9 1.0 C2' 2:T44129 4.7 30.0 0.2 CA 2:LEU17 4.8 19.0 1.0 C 2:LYS15 4.8 20.5 1.0 CD1 2:LEU110 4.9 18.2 1.0 C 2:VAL16 4.9 19.7 1.0 CA 2:VAL16 4.9 19.3 1.0 CD2 2:LEU17 4.9 22.1 1.0

J.A.Hamilton, L.K.Steinrauf, B.C.Braden, J.Liepnieks, M.D.Benson, G.Holmgren, O.Sandgren, L.Steen. The X-Ray Crystal Structure Refinements of Normal Human Transthyretin and the Amyloidogenic Val-30-->Met Variant to 1.7-A Resolution. J.Biol.Chem. V. 268 2416 1993.
ISSN: ISSN 0021-9258
PubMed: 8428915