Atomistry » Iodine » PDB 1q0t-1v1f » 1u65
Atomistry »
  Iodine »
    PDB 1q0t-1v1f »
      1u65 »

Iodine in PDB 1u65: Ache W. Cpt-11

Enzymatic activity of Ache W. Cpt-11

All present enzymatic activity of Ache W. Cpt-11:
3.1.1.7;

Protein crystallography data

The structure of Ache W. Cpt-11, PDB code: 1u65 was solved by M.Harel, J.L.Hyatt, B.Brumshtein, C.L.Morton, R.W.Wadkins, I.Silman, J.L.Sussman, P.M.Potter, Israel Structural Proteomics Center (Ispc), with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 27.88 / 2.61
Space group P 32 2 1
Cell size a, b, c (Å), α, β, γ (°) 137.870, 137.870, 70.890, 90.00, 90.00, 120.00
R / Rfree (%) 18.7 / 23.7

Iodine Binding Sites:

The binding sites of Iodine atom in the Ache W. Cpt-11 (pdb code 1u65). This binding sites where shown within 5.0 Angstroms radius around Iodine atom.
In total only one binding site of Iodine was determined in the Ache W. Cpt-11, PDB code: 1u65:

Iodine binding site 1 out of 1 in 1u65

Go back to Iodine Binding Sites List in 1u65
Iodine binding site 1 out of 1 in the Ache W. Cpt-11


Mono view


Stereo pair view

A full contact list of Iodine with other atoms in the I binding site number 1 of Ache W. Cpt-11 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:I1001

b:66.2
occ:0.60
OE1 A:GLU268 2.7 34.8 1.0
OE2 A:GLU268 2.8 36.1 1.0
NE2 A:HIS264 2.9 43.6 1.0
CD A:GLU268 3.0 36.3 1.0
CD2 A:HIS264 3.2 43.5 1.0
CE1 A:HIS264 4.1 44.6 1.0
CG A:GLU268 4.4 37.5 1.0
CG A:HIS264 4.5 43.8 1.0
O A:HOH1164 4.9 38.0 1.0
ND1 A:HIS264 4.9 45.7 1.0

Reference:

M.Harel, J.L.Hyatt, B.Brumshtein, C.L.Morton, K.J.Yoon, R.M.Wadkins, I.Silman, J.L.Sussman, P.M.Potter. The Crystal Structure of the Complex of the Anticancer Prodrug 7-Ethyl-10-[4-(1-Piperidino)-1-Piperidino]- Carbonyloxycamptothecin (Cpt-11) with Torpedo Californica Acetylcholinesterase Provides A Molecular Explanation For Its Cholinergic Action Mol.Pharmacol. V. 67 1874 2005.
ISSN: ISSN 0026-895X
PubMed: 15772291
DOI: 10.1124/MOL.104.009944
Page generated: Sun Aug 11 12:53:17 2024

Last articles

Zn in 9JYW
Zn in 9IR4
Zn in 9IR3
Zn in 9GMX
Zn in 9GMW
Zn in 9JEJ
Zn in 9ERF
Zn in 9ERE
Zn in 9EGV
Zn in 9EGW
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy