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Iodine in PDB 1vj5: Human Soluble Epoxide Hydrolase- N-Cyclohexyl-N'-(4-Iodophenyl)Urea Complex

Enzymatic activity of Human Soluble Epoxide Hydrolase- N-Cyclohexyl-N'-(4-Iodophenyl)Urea Complex

All present enzymatic activity of Human Soluble Epoxide Hydrolase- N-Cyclohexyl-N'-(4-Iodophenyl)Urea Complex:
3.3.2.3;

Protein crystallography data

The structure of Human Soluble Epoxide Hydrolase- N-Cyclohexyl-N'-(4-Iodophenyl)Urea Complex, PDB code: 1vj5 was solved by G.A.Gomez, C.Morisseau, B.D.Hammock, D.W.Christianson, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 48.94 / 2.35
Space group P 65 2 2
Cell size a, b, c (Å), α, β, γ (°) 93.510, 93.510, 245.700, 90.00, 90.00, 120.00
R / Rfree (%) 21.7 / 26.6

Other elements in 1vj5:

The structure of Human Soluble Epoxide Hydrolase- N-Cyclohexyl-N'-(4-Iodophenyl)Urea Complex also contains other interesting chemical elements:

Magnesium (Mg) 1 atom

Iodine Binding Sites:

The binding sites of Iodine atom in the Human Soluble Epoxide Hydrolase- N-Cyclohexyl-N'-(4-Iodophenyl)Urea Complex (pdb code 1vj5). This binding sites where shown within 5.0 Angstroms radius around Iodine atom.
In total only one binding site of Iodine was determined in the Human Soluble Epoxide Hydrolase- N-Cyclohexyl-N'-(4-Iodophenyl)Urea Complex, PDB code: 1vj5:

Iodine binding site 1 out of 1 in 1vj5

Go back to Iodine Binding Sites List in 1vj5
Iodine binding site 1 out of 1 in the Human Soluble Epoxide Hydrolase- N-Cyclohexyl-N'-(4-Iodophenyl)Urea Complex


Mono view


Stereo pair view

A full contact list of Iodine with other atoms in the I binding site number 1 of Human Soluble Epoxide Hydrolase- N-Cyclohexyl-N'-(4-Iodophenyl)Urea Complex within 5.0Å range:
probe atom residue distance (Å) B Occ
A:I781

b:88.1
occ:1.00
 I4 A:CIU781 0.0 88.1 1.0
C11 A:CIU781 2.1 73.9 1.0
C10 A:CIU781 3.0 72.3 1.0
C12 A:CIU781 3.1 71.8 1.0
CD2 A:LEU406 3.2 23.7 1.0
CE A:MET418 3.7 47.4 1.0
CD2 A:LEU427 3.8 37.9 1.0
CG A:LEU406 4.4 24.5 1.0
C9 A:CIU781 4.4 66.8 1.0
C13 A:CIU781 4.4 66.2 1.0
CD1 A:LEU406 4.5 22.8 1.0
SD A:MET418 4.6 48.4 1.0
CG A:LEU427 4.7 39.1 1.0
CD1 A:LEU427 4.7 37.6 1.0
CD1 A:LEU416 4.7 48.8 1.0
CZ A:PHE385 4.9 22.7 1.0
C8 A:CIU781 5.0 62.6 1.0

Reference:

G.A.Gomez, C.Morisseau, B.D.Hammock, D.W.Christianson. Structure of Human Epoxide Hydrolase Reveals Mechanistic Inferences on Bifunctional Catalysis in Epoxide and Phosphate Ester Hydrolysis Biochemistry V. 43 4716 2004.
ISSN: ISSN 0006-2960
PubMed: 15096040
DOI: 10.1021/BI036189J
Page generated: Sun Aug 11 12:58:43 2024

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