Iodine in PDB 2ckl: RING1B-BMI1 E3 Catalytic Domain Structure

The structure of RING1B-BMI1 E3 Catalytic Domain Structure, PDB code: 2ckl was solved by G.Buchwald, P.Van Der Stoop, O.Weichenrieder, A.Perrakis, M.Van Lohuizen, T.K.Sixma, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	30.00 / 2.0
Space group	P 63
Cell size a, b, c (Å), α, β, γ (°)	120.046, 120.046, 27.096, 90.00, 90.00, 120.00
R / Rfree (%)	17.9 / 21.3

The structure of RING1B-BMI1 E3 Catalytic Domain Structure also contains other interesting chemical elements:

Zinc

(Zn)

4 atoms

The binding sites of Iodine atom in the RING1B-BMI1 E3 Catalytic Domain Structure (pdb code 2ckl). This binding sites where shown within 5.0 Angstroms radius around Iodine atom.
In total 2 binding sites of Iodine where determined in the RING1B-BMI1 E3 Catalytic Domain Structure, PDB code: 2ckl:
Jump to Iodine binding site number: 1; 2;

Iodine binding site 1 out of 2 in the RING1B-BMI1 E3 Catalytic Domain Structure


Mono view


Stereo pair view

A full contact list of Iodine with other atoms in the I binding site number 1 of RING1B-BMI1 E3 Catalytic Domain Structure within 5.0Å range: probe atom residue distance (Å) B Occ A:I1106 b:29.4 occ:0.58 CG1 A:VAL19 4.2 39.4 1.0 CA A:VAL19 4.2 38.1 1.0 CB A:VAL19 4.5 37.9 1.0 O A:CYS18 4.7 37.7 1.0 CA A:GLY22 4.7 38.8 1.0 N A:VAL19 4.9 37.0 1.0 O A:VAL19 4.9 37.2 1.0

Iodine binding site 2 out of 2 in the RING1B-BMI1 E3 Catalytic Domain Structure


Mono view


Stereo pair view

A full contact list of Iodine with other atoms in the I binding site number 2 of RING1B-BMI1 E3 Catalytic Domain Structure within 5.0Å range: probe atom residue distance (Å) B Occ B:I1117 b:63.3 occ:0.35 CB B:LEU80 3.9 25.5 1.0 C B:LEU80 4.2 24.0 1.0 O B:LEU80 4.3 23.2 1.0 NZ B:LYS85 4.3 51.2 1.0 N B:ARG81 4.4 23.0 1.0 CE B:LYS85 4.4 50.4 1.0 CA B:SER96 4.7 51.2 1.0 N B:LYS97 4.7 52.0 1.0 CA B:ARG81 4.7 22.6 1.0 CA B:LEU80 4.7 24.9 1.0 CG B:LEU80 5.0 28.6 1.0

G.Buchwald, P.Van Der Stoop, O.Weichenrieder, A.Perrakis, M.Van Lohuizen, T.K.Sixma. Structure and E3-Ligase Activity of the Ring-Ring Complex of Polycomb Proteins BMI1 and RING1B. Embo J. V. 25 2465 2006.
ISSN: ISSN 0261-4189
PubMed: 16710298
DOI: 10.1038/SJ.EMBOJ.7601144