Iodine in PDB 2nll: Retinoid X Receptor-Thyroid Hormone Receptor Dna-Binding Domain Heterodimer Bound to Thyroid Response Element Dna

The structure of Retinoid X Receptor-Thyroid Hormone Receptor Dna-Binding Domain Heterodimer Bound to Thyroid Response Element Dna, PDB code: 2nll was solved by F.Rastinejad, T.Perlmann, R.M.Evans, P.B.Sigler, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	6.00 / 1.90
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	40.900, 65.600, 125.700, 90.00, 90.00, 90.00
R / Rfree (%)	20.6 / 26.9

The structure of Retinoid X Receptor-Thyroid Hormone Receptor Dna-Binding Domain Heterodimer Bound to Thyroid Response Element Dna also contains other interesting chemical elements:

Zinc

(Zn)

4 atoms

The binding sites of Iodine atom in the Retinoid X Receptor-Thyroid Hormone Receptor Dna-Binding Domain Heterodimer Bound to Thyroid Response Element Dna (pdb code 2nll). This binding sites where shown within 5.0 Angstroms radius around Iodine atom.
In total only one binding site of Iodine was determined in the Retinoid X Receptor-Thyroid Hormone Receptor Dna-Binding Domain Heterodimer Bound to Thyroid Response Element Dna, PDB code: 2nll:

Iodine binding site 1 out of 1 in the Retinoid X Receptor-Thyroid Hormone Receptor Dna-Binding Domain Heterodimer Bound to Thyroid Response Element Dna


Mono view


Stereo pair view

A full contact list of Iodine with other atoms in the I binding site number 1 of Retinoid X Receptor-Thyroid Hormone Receptor Dna-Binding Domain Heterodimer Bound to Thyroid Response Element Dna within 5.0Å range: probe atom residue distance (Å) B Occ C:I511 b:59.0 occ:1.00 I5 C:5IU511 0.0 59.0 1.0 C5 C:5IU511 2.1 31.9 1.0 C6 C:5IU511 3.0 30.7 1.0 C4 C:5IU511 3.1 24.6 1.0 O4 C:5IU511 3.3 23.4 1.0 O C:HOH629 3.5 20.3 1.0 C6 C:DT510 3.7 28.5 1.0 O C:HOH797 3.8 33.7 1.0 N4 C:DC512 4.0 18.2 1.0 C2' C:DT510 4.0 34.9 1.0 N1 C:DT510 4.1 30.2 1.0 C5 C:DT510 4.1 27.1 1.0 N1 C:5IU511 4.3 26.6 1.0 N3 C:5IU511 4.4 18.8 1.0 C7 C:DT510 4.4 27.5 1.0 C1' C:DT510 4.6 32.8 1.0 C4 C:DC512 4.6 19.9 1.0 C2 C:DT510 4.7 26.8 1.0 C4 C:DT510 4.7 22.9 1.0 C5 C:DC512 4.8 18.3 1.0 C2 C:5IU511 4.9 25.5 1.0 N3 C:DT510 5.0 22.4 1.0

F.Rastinejad, T.Perlmann, R.M.Evans, P.B.Sigler. Structural Determinants of Nuclear Receptor Assembly on Dna Direct Repeats. Nature V. 375 203 1995.
ISSN: ISSN 0028-0836
PubMed: 7746322
DOI: 10.1038/375203A0