Iodine in PDB 2ycz: Turkey BETA1 Adrenergic Receptor with Stabilising Mutations and Bound Antagonist Iodocyanopindolol

The structure of Turkey BETA1 Adrenergic Receptor with Stabilising Mutations and Bound Antagonist Iodocyanopindolol, PDB code: 2ycz was solved by R.Moukhametzianov, T.Warne, P.C.Edwards, M.J.Serrano-Vega, A.G.W.Leslie, C.G.Tate, G.F.X.Schertler, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	41.31 / 3.65
Space group	C 1 2 1
Cell size a, b, c (Å), α, β, γ (°)	177.855, 56.298, 110.939, 90.00, 116.39, 90.00
R / Rfree (%)	24.9 / 27

The binding sites of Iodine atom in the Turkey BETA1 Adrenergic Receptor with Stabilising Mutations and Bound Antagonist Iodocyanopindolol (pdb code 2ycz). This binding sites where shown within 5.0 Angstroms radius around Iodine atom.
In total 2 binding sites of Iodine where determined in the Turkey BETA1 Adrenergic Receptor with Stabilising Mutations and Bound Antagonist Iodocyanopindolol, PDB code: 2ycz:
Jump to Iodine binding site number: 1; 2;

Iodine binding site 1 out of 2 in the Turkey BETA1 Adrenergic Receptor with Stabilising Mutations and Bound Antagonist Iodocyanopindolol


Mono view


Stereo pair view

A full contact list of Iodine with other atoms in the I binding site number 1 of Turkey BETA1 Adrenergic Receptor with Stabilising Mutations and Bound Antagonist Iodocyanopindolol within 5.0Å range: probe atom residue distance (Å) B Occ A:I400 b:0.3 occ:0.30 IAA A:I32400 0.0 0.3 0.3 C2 A:I32400 2.1 82.3 0.8 C1 A:I32400 3.1 83.3 0.8 C3 A:I32400 3.2 78.2 0.8 C16 A:I32400 3.3 85.8 0.8 O1 A:I32400 3.4 72.1 0.8 CD2 A:PHE201 3.7 0.5 1.0 OD1 A:ASN310 3.7 0.4 1.0 C4 A:I32400 3.7 74.4 0.8 CE2 A:PHE201 3.8 89.5 1.0 NAF A:I32400 3.8 88.4 0.8 CZ A:PHE306 4.1 83.0 1.0 ND2 A:ASN310 4.1 0.8 1.0 CE1 A:PHE306 4.1 71.7 1.0 CG A:ASN310 4.1 0.7 1.0 N1 A:I32400 4.2 80.8 0.8 C8 A:I32400 4.3 77.9 0.8 C11 A:I32400 4.6 72.5 0.8 C13 A:I32400 4.6 61.6 0.8 C9 A:I32400 4.7 70.1 0.8 CG A:PHE201 4.9 98.4 1.0

Iodine binding site 2 out of 2 in the Turkey BETA1 Adrenergic Receptor with Stabilising Mutations and Bound Antagonist Iodocyanopindolol


Mono view


Stereo pair view

A full contact list of Iodine with other atoms in the I binding site number 2 of Turkey BETA1 Adrenergic Receptor with Stabilising Mutations and Bound Antagonist Iodocyanopindolol within 5.0Å range: probe atom residue distance (Å) B Occ B:I400 b:92.6 occ:0.30 IAA B:I32400 0.0 92.6 0.3 C2 B:I32400 2.1 66.7 0.8 C1 B:I32400 3.1 68.0 0.8 C3 B:I32400 3.1 59.8 0.8 C16 B:I32400 3.3 69.5 0.8 O1 B:I32400 3.3 50.8 0.8 CD2 B:PHE201 3.5 99.5 1.0 CE2 B:PHE201 3.6 86.4 1.0 C4 B:I32400 3.7 53.8 0.8 NAF B:I32400 3.8 72.2 0.8 OD1 B:ASN310 4.0 0.2 1.0 CZ B:PHE306 4.2 82.1 1.0 N1 B:I32400 4.2 64.6 0.8 C8 B:I32400 4.2 60.0 0.8 CE1 B:PHE306 4.2 71.0 1.0 ND2 B:ASN310 4.4 0.5 1.0 CG B:ASN310 4.4 0.7 1.0 C13 B:I32400 4.5 69.9 0.8 C11 B:I32400 4.5 60.8 0.8 C9 B:I32400 4.6 49.1 0.8 CG B:PHE201 4.7 95.6 1.0 CZ B:PHE201 4.8 79.2 1.0 C10 B:I32400 5.0 49.9 0.8

R.Moukhametzianov, T.Warne, P.C.Edwards, M.J.Serrano-Vega, A.G.Leslie, C.G.Tate, G.F.Schertler. Two Distinct Conformations of Helix 6 Observed in Antagonist-Bound Structures of A {Beta}1- Adrenergic Receptor. Proc.Natl.Acad.Sci.Usa V. 108 8228 2011.
ISSN: ISSN 0027-8424
PubMed: 21540331
DOI: 10.1073/PNAS.1100185108