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Atomistry » Iodine » PDB 3cjq-3fnl » 3e8n | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Iodine » PDB 3cjq-3fnl » 3e8n » |
Iodine in PDB 3e8n: X-Ray Structure of the Human Mitogen-Activated Protein Kinase Kinase 1 (MEK1) Complexed with A Potent Inhibitor RDEA119 and MgatpEnzymatic activity of X-Ray Structure of the Human Mitogen-Activated Protein Kinase Kinase 1 (MEK1) Complexed with A Potent Inhibitor RDEA119 and Mgatp
All present enzymatic activity of X-Ray Structure of the Human Mitogen-Activated Protein Kinase Kinase 1 (MEK1) Complexed with A Potent Inhibitor RDEA119 and Mgatp:
2.7.12.2; Protein crystallography data
The structure of X-Ray Structure of the Human Mitogen-Activated Protein Kinase Kinase 1 (MEK1) Complexed with A Potent Inhibitor RDEA119 and Mgatp, PDB code: 3e8n
was solved by
S.Yan,
Z.M.Wang,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 3e8n:
The structure of X-Ray Structure of the Human Mitogen-Activated Protein Kinase Kinase 1 (MEK1) Complexed with A Potent Inhibitor RDEA119 and Mgatp also contains other interesting chemical elements:
Iodine Binding Sites:
The binding sites of Iodine atom in the X-Ray Structure of the Human Mitogen-Activated Protein Kinase Kinase 1 (MEK1) Complexed with A Potent Inhibitor RDEA119 and Mgatp
(pdb code 3e8n). This binding sites where shown within
5.0 Angstroms radius around Iodine atom.
In total only one binding site of Iodine was determined in the X-Ray Structure of the Human Mitogen-Activated Protein Kinase Kinase 1 (MEK1) Complexed with A Potent Inhibitor RDEA119 and Mgatp, PDB code: 3e8n: Iodine binding site 1 out of 1 in 3e8nGo back to Iodine Binding Sites List in 3e8n
Iodine binding site 1 out
of 1 in the X-Ray Structure of the Human Mitogen-Activated Protein Kinase Kinase 1 (MEK1) Complexed with A Potent Inhibitor RDEA119 and Mgatp
Mono view Stereo pair view
Reference:
C.Iverson,
G.Larson,
C.Lai,
L.T.Yeh,
C.Dadson,
P.Weingarten,
T.Appleby,
T.Vo,
A.Maderna,
J.M.Vernier,
R.Hamatake,
J.N.Miner,
B.Quart.
RDEA119/Bay 869766: A Potent, Selective, Allosteric Inhibitor of MEK1/2 For the Treatment of Cancer. Cancer Res. V. 69 6839 2009.
Page generated: Sun Dec 13 19:27:01 2020
ISSN: ISSN 0008-5472 PubMed: 19706763 DOI: 10.1158/0008-5472.CAN-09-0679 |
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