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Iodine in PDB 3eqb: X-Ray Structure of the Human Mitogen-Activated Protein Kinase Kinase 1 (MEK1) in A Complex with Ligand and Mgatp
Enzymatic activity of X-Ray Structure of the Human Mitogen-Activated Protein Kinase Kinase 1 (MEK1) in A Complex with Ligand and Mgatp
All present enzymatic activity of X-Ray Structure of the Human Mitogen-Activated Protein Kinase Kinase 1 (MEK1) in A Complex with Ligand and Mgatp:
2.7.12.2;
2.7.12.2;
Protein crystallography data
The structure of X-Ray Structure of the Human Mitogen-Activated Protein Kinase Kinase 1 (MEK1) in A Complex with Ligand and Mgatp, PDB code: 3eqb
was solved by
J.F.Ohren,
A.Pavlovsky,
E.Zhang,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 20.00 / 2.62 |
| Space group | P 62 |
| Cell size a, b, c (Å), α, β, γ (°) | 82.128, 82.128, 129.099, 90.00, 90.00, 120.00 |
| R / Rfree (%) | 21 / 26.4 |
Other elements in 3eqb:
The structure of X-Ray Structure of the Human Mitogen-Activated Protein Kinase Kinase 1 (MEK1) in A Complex with Ligand and Mgatp also contains other interesting chemical elements:
| Fluorine | (F) | 3 atoms |
| Magnesium | (Mg) | 1 atom |
Iodine Binding Sites:
The binding sites of Iodine atom in the X-Ray Structure of the Human Mitogen-Activated Protein Kinase Kinase 1 (MEK1) in A Complex with Ligand and Mgatp
(pdb code 3eqb). This binding sites where shown within
5.0 Angstroms radius around Iodine atom.
In total only one binding site of Iodine was determined in the X-Ray Structure of the Human Mitogen-Activated Protein Kinase Kinase 1 (MEK1) in A Complex with Ligand and Mgatp, PDB code: 3eqb:
In total only one binding site of Iodine was determined in the X-Ray Structure of the Human Mitogen-Activated Protein Kinase Kinase 1 (MEK1) in A Complex with Ligand and Mgatp, PDB code: 3eqb:
Iodine binding site 1 out of 1 in 3eqb
Go back to
Iodine Binding Sites List in 3eqb
Iodine binding site 1 out
of 1 in the X-Ray Structure of the Human Mitogen-Activated Protein Kinase Kinase 1 (MEK1) in A Complex with Ligand and Mgatp
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Iodine with other atoms in the I binding
site number 1 of X-Ray Structure of the Human Mitogen-Activated Protein Kinase Kinase 1 (MEK1) in A Complex with Ligand and Mgatp within 5.0Å range:
|
Reference:
J.S.Warmus,
C.Flamme,
L.Y.Zhang,
S.Barrett,
A.Bridges,
H.Chen,
R.Gowan,
M.Kaufman,
J.Sebolt-Leopold,
W.Leopold,
R.Merriman,
J.Ohren,
A.Pavlovsky,
S.Przybranowski,
H.Tecle,
H.Valik,
C.Whitehead,
E.Zhang.
2-Alkylamino- and Alkoxy-Substituted 2-Amino-1,3,4-Oxadiazoles-O-Alkyl Benzohydroxamate Esters Replacements Retain the Desired Inhibition and Selectivity Against Mek (Map Erk Kinase). Bioorg.Med.Chem.Lett. V. 18 6171 2008.
ISSN: ISSN 0960-894X
PubMed: 18951019
DOI: 10.1016/J.BMCL.2008.10.015
Page generated: Sun Dec 13 19:27:07 2020
ISSN: ISSN 0960-894X
PubMed: 18951019
DOI: 10.1016/J.BMCL.2008.10.015
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