Iodine in PDB 3hhc: Interferon-Lambda Is Functionally An Interferon But Structurally Related to the Il-10 Family

The structure of Interferon-Lambda Is Functionally An Interferon But Structurally Related to the Il-10 Family, PDB code: 3hhc was solved by H.H.Gad, O.J.Hamming, R.Hartmann, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	23.86 / 2.80
Space group	P 31 2 1
Cell size a, b, c (Å), α, β, γ (°)	91.118, 91.118, 150.209, 90.00, 90.00, 120.00
R / Rfree (%)	26.1 / 31.4

Pages:

>>> Page 1 <<< Page 2, Binding sites: 11 - 20; Page 3, Binding sites: 21 - 30; Page 4, Binding sites: 31 - 35;

Binding sites:

The binding sites of Iodine atom in the Interferon-Lambda Is Functionally An Interferon But Structurally Related to the Il-10 Family (pdb code 3hhc). This binding sites where shown within 5.0 Angstroms radius around Iodine atom.
In total 35 binding sites of Iodine where determined in the Interferon-Lambda Is Functionally An Interferon But Structurally Related to the Il-10 Family, PDB code: 3hhc:
Jump to Iodine binding site number: 1; 2; 3; 4; 5; 6; 7; 8; 9; 10;

Iodine binding site 1 out of 35 in the Interferon-Lambda Is Functionally An Interferon But Structurally Related to the Il-10 Family


Mono view


Stereo pair view

A full contact list of Iodine with other atoms in the I binding site number 1 of Interferon-Lambda Is Functionally An Interferon But Structurally Related to the Il-10 Family within 5.0Å range: probe atom residue distance (Å) B Occ A:I164 b:82.9 occ:1.00 OG1 A:THR92 3.3 68.2 1.0 CB A:GLU16 4.0 64.7 1.0 O A:GLN88 4.0 59.8 1.0 CB A:ALA19 4.1 36.5 1.0 CA A:GLU16 4.1 60.4 1.0 C A:GLN88 4.1 65.6 1.0 N A:PRO89 4.2 65.4 1.0 CA A:PRO89 4.2 61.9 1.0 CE1 A:PHE20 4.2 56.9 1.0 CB A:THR92 4.2 65.9 1.0 CG A:GLN88 4.3 93.7 1.0 CG A:GLU16 4.4 79.9 1.0 CB A:GLN88 4.4 78.8 1.0 O A:GLU16 4.5 52.7 1.0 CZ A:PHE20 4.7 41.6 1.0 CD1 A:PHE20 4.7 53.5 1.0 OE2 A:GLU16 4.7 0.0 1.0 C A:GLU16 4.8 58.0 1.0 CD A:PRO89 4.8 60.0 1.0 CG2 A:THR92 4.9 70.7 1.0 CA A:GLN88 4.9 64.2 1.0

Iodine binding site 2 out of 35 in the Interferon-Lambda Is Functionally An Interferon But Structurally Related to the Il-10 Family


Mono view


Stereo pair view

A full contact list of Iodine with other atoms in the I binding site number 2 of Interferon-Lambda Is Functionally An Interferon But Structurally Related to the Il-10 Family within 5.0Å range: probe atom residue distance (Å) B Occ A:I165 b:89.8 occ:0.93 O A:ARG50 4.0 57.0 1.0 CA A:GLN51 4.2 68.8 1.0 C A:ARG50 4.3 54.9 1.0 N A:GLN51 4.3 56.0 1.0 CG A:GLN51 4.3 74.3 1.0 CB A:ARG50 4.7 66.9 1.0 CB A:GLN51 4.8 68.0 1.0 OXT A:VAL163 4.8 79.5 1.0

Iodine binding site 3 out of 35 in the Interferon-Lambda Is Functionally An Interferon But Structurally Related to the Il-10 Family


Mono view


Stereo pair view

A full contact list of Iodine with other atoms in the I binding site number 3 of Interferon-Lambda Is Functionally An Interferon But Structurally Related to the Il-10 Family within 5.0Å range: probe atom residue distance (Å) B Occ A:I166 b:92.7 occ:1.00 CD A:LYS24 3.8 83.0 1.0 O A:PHE20 3.9 49.2 1.0 CB A:PHE146 3.9 45.4 1.0 CD1 A:LEU145 4.0 43.2 1.0 CB A:LYS24 4.0 63.4 1.0 N A:PHE146 4.0 58.0 1.0 CA A:PHE146 4.0 51.7 1.0 C A:PHE20 4.1 50.2 1.0 CB A:PHE20 4.2 46.7 1.0 N A:LYS21 4.3 50.4 1.0 CB A:LEU145 4.4 45.7 1.0 CA A:LYS21 4.4 54.3 1.0 CG A:LYS24 4.5 73.9 1.0 CD2 A:PHE146 4.5 64.1 1.0 CG A:PHE146 4.7 59.4 1.0 CG A:LEU145 4.7 44.8 1.0 CD1 A:LEU149 4.7 70.7 1.0 C A:LEU145 4.8 51.8 1.0 CA A:PHE20 4.8 51.5 1.0 CE A:LYS24 5.0 90.9 1.0

Iodine binding site 4 out of 35 in the Interferon-Lambda Is Functionally An Interferon But Structurally Related to the Il-10 Family


Mono view


Stereo pair view

A full contact list of Iodine with other atoms in the I binding site number 4 of Interferon-Lambda Is Functionally An Interferon But Structurally Related to the Il-10 Family within 5.0Å range: probe atom residue distance (Å) B Occ A:I167 b:87.7 occ:0.66 CD A:LYS70 4.0 92.1 1.0 CG2 A:VAL71 4.0 89.0 1.0 CB A:PRO129 4.2 60.9 1.0 CA A:VAL71 4.2 80.8 1.0 CE A:LYS70 4.3 84.0 1.0 CG A:LYS70 4.3 91.6 1.0 N A:VAL71 4.4 77.7 1.0 CB A:VAL71 4.7 84.1 1.0 CG A:PRO129 4.7 54.0 1.0 C A:LYS70 4.8 78.8 1.0 CB A:ALA74 4.8 54.2 1.0 CA A:PRO129 4.9 75.9 1.0 O A:LYS70 4.9 87.9 1.0 CB A:LYS70 5.0 78.8 1.0

Iodine binding site 5 out of 35 in the Interferon-Lambda Is Functionally An Interferon But Structurally Related to the Il-10 Family


Mono view


Stereo pair view

A full contact list of Iodine with other atoms in the I binding site number 5 of Interferon-Lambda Is Functionally An Interferon But Structurally Related to the Il-10 Family within 5.0Å range: probe atom residue distance (Å) B Occ A:I168 b:98.0 occ:0.80 N A:GLN53 3.8 46.2 1.0 CD2 A:LEU52 3.9 54.0 1.0 CA A:LEU52 4.1 59.1 1.0 CB A:LEU52 4.1 51.6 1.0 OE1 A:GLN53 4.2 99.9 1.0 CB A:GLU56 4.4 63.7 1.0 CG A:GLU56 4.5 86.3 1.0 CG A:ARG117 4.5 0.3 1.0 N A:GLY116 4.5 0.7 1.0 C A:LEU52 4.5 56.4 1.0 CB A:GLN53 4.6 66.6 1.0 CB A:LEU118 4.6 98.4 1.0 CG A:LEU52 4.6 51.0 1.0 CG A:GLN53 4.7 80.8 1.0 CD A:GLN53 4.8 97.9 1.0 CA A:GLN53 4.8 52.2 1.0

Iodine binding site 6 out of 35 in the Interferon-Lambda Is Functionally An Interferon But Structurally Related to the Il-10 Family


Mono view


Stereo pair view

A full contact list of Iodine with other atoms in the I binding site number 6 of Interferon-Lambda Is Functionally An Interferon But Structurally Related to the Il-10 Family within 5.0Å range: probe atom residue distance (Å) B Occ A:I169 b:0.0 occ:0.59 CG A:GLU29 3.4 74.2 1.0 N C:ARG45 3.5 76.4 1.0 NH1 C:ARG41 3.7 0.9 1.0 CB C:ARG45 3.9 80.2 1.0 CZ C:ARG41 4.1 0.6 1.0 CA C:ARG45 4.2 78.4 1.0 CG2 C:THR46 4.2 64.9 1.0 CD A:GLU29 4.2 87.0 1.0 CG C:ARG45 4.3 76.9 1.0 N C:THR46 4.4 67.1 1.0 C C:PRO44 4.4 71.4 1.0 OE2 A:GLU29 4.5 94.7 1.0 CA C:PRO44 4.5 65.5 1.0 CB A:GLU29 4.5 69.8 1.0 C C:ARG45 4.5 77.8 1.0 NE C:ARG41 4.6 0.4 1.0 NH2 C:ARG41 4.7 0.9 1.0 CD C:ARG41 4.7 0.1 1.0 CB C:PRO44 4.8 49.7 1.0 OG1 C:THR46 5.0 88.7 1.0

Iodine binding site 7 out of 35 in the Interferon-Lambda Is Functionally An Interferon But Structurally Related to the Il-10 Family


Mono view


Stereo pair view

A full contact list of Iodine with other atoms in the I binding site number 7 of Interferon-Lambda Is Functionally An Interferon But Structurally Related to the Il-10 Family within 5.0Å range: probe atom residue distance (Å) B Occ A:I170 b:0.8 occ:0.64 CD1 A:TRP47 3.4 80.3 1.0 NH1 A:ARG124 3.4 0.1 1.0 NE1 A:TRP47 3.7 82.8 1.0 CD2 A:HIS120 3.8 0.4 1.0 CD1 A:TRP121 3.9 95.5 1.0 NH2 A:ARG124 4.1 0.2 1.0 CB A:TRP121 4.1 91.4 1.0 CZ A:ARG124 4.2 0.5 1.0 CA A:TRP121 4.3 88.7 1.0 CG A:TRP47 4.3 78.4 1.0 CG A:TRP121 4.4 89.8 1.0 N A:TRP121 4.6 91.2 1.0 NE2 A:HIS120 4.6 0.9 1.0 CE2 A:TRP47 4.7 81.1 1.0 CG A:HIS120 4.9 0.9 1.0 O A:HOH208 4.9 64.0 1.0

Iodine binding site 8 out of 35 in the Interferon-Lambda Is Functionally An Interferon But Structurally Related to the Il-10 Family


Mono view


Stereo pair view

A full contact list of Iodine with other atoms in the I binding site number 8 of Interferon-Lambda Is Functionally An Interferon But Structurally Related to the Il-10 Family within 5.0Å range: probe atom residue distance (Å) B Occ A:I171 b:86.4 occ:1.00 CE1 A:PHE146 3.7 40.9 1.0 CD1 A:PHE146 3.7 44.9 1.0 NH2 A:ARG45 3.8 1.0 1.0 CA A:ARG147 3.8 42.8 1.0 CB A:ARG147 3.8 25.8 1.0 CG A:ARG147 4.0 29.9 1.0 CE C:LYS21 4.0 81.2 1.0 NZ C:LYS21 4.2 90.5 1.0 OG1 A:THR150 4.3 73.1 1.0 CB A:ARG151 4.4 48.8 1.0 N A:ARG147 4.4 50.3 1.0 CD A:ARG147 4.5 52.5 1.0 NH2 A:ARG151 4.5 0.7 1.0 CD A:ARG151 4.7 75.9 1.0 CZ A:ARG45 4.7 0.1 1.0 OD2 C:ASP25 4.9 75.6 1.0 O A:HOH185 4.9 0.2 1.0 CZ A:PHE146 5.0 51.5 1.0

Iodine binding site 9 out of 35 in the Interferon-Lambda Is Functionally An Interferon But Structurally Related to the Il-10 Family


Mono view


Stereo pair view

A full contact list of Iodine with other atoms in the I binding site number 9 of Interferon-Lambda Is Functionally An Interferon But Structurally Related to the Il-10 Family within 5.0Å range: probe atom residue distance (Å) B Occ A:I172 b:0.7 occ:0.68 OD1 A:ASP48 3.1 0.6 1.0 OD2 A:ASP48 3.2 99.1 1.0 NE A:ARG50 3.3 93.8 1.0 OD1 A:ASP152 3.5 72.6 1.0 CG A:ASP48 3.5 96.6 1.0 CG A:ARG50 3.7 68.3 1.0 CG A:ARG151 3.7 56.9 1.0 CB A:CYS155 3.7 41.7 1.0 CD A:ARG50 3.9 79.5 1.0 SG A:CYS155 4.0 63.4 1.0 O A:ARG151 4.0 48.0 1.0 NE A:ARG151 4.1 97.8 1.0 CB A:LEU49 4.1 61.0 1.0 CZ A:ARG50 4.1 0.8 1.0 N A:LEU49 4.2 73.3 1.0 NH2 A:ARG50 4.2 1.0 1.0 N A:ARG50 4.3 58.1 1.0 CA A:ASP152 4.3 44.5 1.0 C A:ARG151 4.3 46.0 1.0 CD A:ARG151 4.5 75.9 1.0 N A:ASP152 4.5 40.3 1.0 CA A:LEU49 4.6 69.2 1.0 CG A:ASP152 4.6 64.3 1.0 CZ A:ARG151 4.7 1.0 1.0 CB A:ARG50 4.8 66.9 1.0 C A:LEU49 4.9 65.8 1.0 CB A:ASP48 4.9 84.0 1.0 CB A:ARG151 4.9 48.8 1.0 NH1 A:ARG151 4.9 0.8 1.0 SG A:CYS162 5.0 56.4 1.0

Iodine binding site 10 out of 35 in the Interferon-Lambda Is Functionally An Interferon But Structurally Related to the Il-10 Family


Mono view


Stereo pair view

A full contact list of Iodine with other atoms in the I binding site number 10 of Interferon-Lambda Is Functionally An Interferon But Structurally Related to the Il-10 Family within 5.0Å range: probe atom residue distance (Å) B Occ A:I173 b:88.8 occ:0.55 O A:HOH186 3.1 52.5 1.0 ND2 A:ASN154 3.2 59.4 1.0 OG A:SER158 3.6 56.7 1.0 CB A:CYS162 3.7 52.4 1.0 SG A:CYS162 3.8 56.4 1.0 CB A:SER158 3.9 51.7 1.0 CA A:CYS162 4.1 51.2 1.0 CA A:CYS155 4.2 36.8 1.0 O A:LEU161 4.3 56.4 1.0 O A:ASN154 4.3 46.3 1.0 NH2 A:ARG50 4.3 1.0 1.0 CG A:ASN154 4.4 64.0 1.0 N A:CYS155 4.4 39.0 1.0 C A:ASN154 4.5 45.4 1.0 NH1 A:ARG50 4.7 0.6 1.0 CB A:CYS155 4.9 41.7 1.0 CZ A:ARG50 4.9 0.8 1.0 N A:CYS162 4.9 50.4 1.0 C A:LEU161 4.9 54.0 1.0 CB A:ASN154 5.0 53.0 1.0

H.H.Gad, C.Dellgren, O.J.Hamming, S.Vends, S.R.Paludan, R.Hartmann. Interferon-{Lambda} Is Functionally An Interferon But Structurally Related to the Interleukin-10 Family J.Biol.Chem. V. 284 20869 2009.
ISSN: ISSN 0021-9258
PubMed: 19457860
DOI: 10.1074/JBC.M109.002923