Iodine in PDB 3sd0: Identification of A Glycogen Synthase Kinase-3B Inhibitor That Attenuates Hyperactivity in Clock Mutant Mice

Enzymatic activity of Identification of A Glycogen Synthase Kinase-3B Inhibitor That Attenuates Hyperactivity in Clock Mutant Mice

All present enzymatic activity of Identification of A Glycogen Synthase Kinase-3B Inhibitor That Attenuates Hyperactivity in Clock Mutant Mice:
2.7.11.26;

Protein crystallography data

The structure of Identification of A Glycogen Synthase Kinase-3B Inhibitor That Attenuates Hyperactivity in Clock Mutant Mice, PDB code: 3sd0 was solved by A.M.Mesecar, R.L.Walters, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

*Resolution Low / High (Å)*	44.95 / 2.70
*Space group*	P 2₁ 2 2₁
*Cell size a, b, c (Å), α, β, γ (°)*	88.505, 96.010, 124.249, 90.00, 90.00, 90.00
*R / R_free (%)*	17.9 / 25.4

Other elements in 3sd0:

The structure of Identification of A Glycogen Synthase Kinase-3B Inhibitor That Attenuates Hyperactivity in Clock Mutant Mice also contains other interesting chemical elements:

Fluorine

(F)

2 atoms

Iodine Binding Sites:

The binding sites of Iodine atom in the Identification of A Glycogen Synthase Kinase-3B Inhibitor That Attenuates Hyperactivity in Clock Mutant Mice (pdb code 3sd0). This binding sites where shown within 5.0 Angstroms radius around Iodine atom.
In total 2 binding sites of Iodine where determined in the Identification of A Glycogen Synthase Kinase-3B Inhibitor That Attenuates Hyperactivity in Clock Mutant Mice, PDB code: 3sd0:
Jump to Iodine binding site number: 1; 2;

Iodine binding site 1 out of 2 in 3sd0

Go back to

Iodine Binding Sites List in 3sd0

Iodine binding site 1 out of 2 in the Identification of A Glycogen Synthase Kinase-3B Inhibitor That Attenuates Hyperactivity in Clock Mutant Mice

Mono view

Stereo pair view

A full contact list of Iodine with other atoms in the I binding site number 1 of Identification of A Glycogen Synthase Kinase-3B Inhibitor That Attenuates Hyperactivity in Clock Mutant Mice within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
A:I400 b:89.9 occ:1.00	I31	A:TSK400	0.0	89.9	1.0
	C24	A:TSK400	2.1	79.2	1.0
	C23	A:TSK400	3.0	77.8	1.0
	C25	A:TSK400	3.0	77.9	1.0
	O	A:ILE62	3.1	60.8	1.0
	F30	A:TSK400	3.1	76.0	1.0
	CA	A:GLY63	3.9	61.5	1.0
	O	A:HOH455	4.0	59.2	1.0
	C	A:ILE62	4.1	59.1	1.0
	O	A:HOH6	4.2	44.4	1.0
	C16	A:TSK400	4.3	79.0	1.0
	C22	A:TSK400	4.3	79.1	1.0
	N	A:GLY63	4.4	59.2	1.0
	C17	A:TSK400	4.7	79.1	1.0
	CG1	A:ILE62	5.0	54.0	1.0

Iodine binding site 2 out of 2 in 3sd0

Go back to

Iodine Binding Sites List in 3sd0

Iodine binding site 2 out of 2 in the Identification of A Glycogen Synthase Kinase-3B Inhibitor That Attenuates Hyperactivity in Clock Mutant Mice

Mono view

Stereo pair view

A full contact list of Iodine with other atoms in the I binding site number 2 of Identification of A Glycogen Synthase Kinase-3B Inhibitor That Attenuates Hyperactivity in Clock Mutant Mice within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
B:I400 b:94.5 occ:1.00	I31	B:TSK400	0.0	94.5	1.0
	C24	B:TSK400	2.1	86.3	1.0
	C25	B:TSK400	3.0	85.7	1.0
	C23	B:TSK400	3.0	85.3	1.0
	F30	B:TSK400	3.2	84.8	1.0
	O	B:ILE62	3.3	79.5	1.0
	CA	B:GLY63	3.8	75.7	1.0
	O	B:HOH21	4.0	51.0	1.0
	C	B:ILE62	4.2	77.5	1.0
	C16	B:TSK400	4.2	86.3	1.0
	C22	B:TSK400	4.3	86.5	1.0
	N	B:GLY63	4.4	75.7	1.0
	C17	B:TSK400	4.7	86.2	1.0

Reference:

A.M.Mesecar, R.L.Walters. Identification of A Glycogen Synthase Kinase-3B Inhibitor That Attenuates Hyperactivity in Clock Mutant Mice To Be Published.

Page generated: Sun Aug 11 16:39:55 2024

Last articles

Zn in 9J0N
Zn in 9J0O
Zn in 9J0P
Zn in 9FJX
Zn in 9EKB
Zn in 9C0F
Zn in 9CAH
Zn in 9CH0
Zn in 9CH3
Zn in 9CH1

	© Copyright 2008-2020 by atomistry.com
Home \| Site Map \| Copyright \| Contact us \| Privacy