Iodine in PDB 3tnz: Crystal Structure of Mus Musculus Iodotyrosine Deiodinase (Iyd) C217A, C239A Bound to Fmn and Mono-Iodotyrosine (Mit)

All present enzymatic activity of Crystal Structure of Mus Musculus Iodotyrosine Deiodinase (Iyd) C217A, C239A Bound to Fmn and Mono-Iodotyrosine (Mit):
1.22.1.1;

The structure of Crystal Structure of Mus Musculus Iodotyrosine Deiodinase (Iyd) C217A, C239A Bound to Fmn and Mono-Iodotyrosine (Mit), PDB code: 3tnz was solved by J.M.Buss, P.M.Mctamney, S.E.Rokita, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	26.54 / 2.25
Space group	P 3
Cell size a, b, c (Å), α, β, γ (°)	108.986, 108.986, 49.399, 90.00, 90.00, 120.00
R / Rfree (%)	17.1 / 20

The binding sites of Iodine atom in the Crystal Structure of Mus Musculus Iodotyrosine Deiodinase (Iyd) C217A, C239A Bound to Fmn and Mono-Iodotyrosine (Mit) (pdb code 3tnz). This binding sites where shown within 5.0 Angstroms radius around Iodine atom.
In total 2 binding sites of Iodine where determined in the Crystal Structure of Mus Musculus Iodotyrosine Deiodinase (Iyd) C217A, C239A Bound to Fmn and Mono-Iodotyrosine (Mit), PDB code: 3tnz:
Jump to Iodine binding site number: 1; 2;

Iodine binding site 1 out of 2 in the Crystal Structure of Mus Musculus Iodotyrosine Deiodinase (Iyd) C217A, C239A Bound to Fmn and Mono-Iodotyrosine (Mit)


Mono view


Stereo pair view

A full contact list of Iodine with other atoms in the I binding site number 1 of Crystal Structure of Mus Musculus Iodotyrosine Deiodinase (Iyd) C217A, C239A Bound to Fmn and Mono-Iodotyrosine (Mit) within 5.0Å range: probe atom residue distance (Å) B Occ A:I302 b:23.5 occ:1.00 IE A:IYR302 0.0 23.5 1.0 CE A:IYR302 2.1 17.1 1.0 CD A:IYR302 3.0 19.8 1.0 CF A:IYR302 3.1 16.1 1.0 OF A:IYR302 3.3 22.3 1.0 N B:ALA126 3.6 21.5 1.0 CA B:GLY125 3.7 14.4 1.0 CB B:TYR207 3.7 16.4 1.0 C B:GLY125 3.9 24.6 1.0 CE1 B:TYR208 3.9 15.2 1.0 CD1 B:TYR208 3.9 16.5 1.0 NE1 A:TRP165 3.9 28.2 1.0 CZ2 A:TRP165 4.1 16.2 1.0 N5 A:FMN301 4.2 19.1 1.0 CG B:TYR207 4.3 16.6 1.0 CC A:IYR302 4.3 18.6 1.0 CG A:IYR302 4.4 14.9 1.0 CE2 A:TRP165 4.4 28.4 1.0 C5A A:FMN301 4.4 18.5 1.0 CB B:ALA126 4.4 22.6 1.0 CA B:ALA126 4.5 19.4 1.0 C6 A:FMN301 4.6 14.6 1.0 OG1 A:THR235 4.6 14.5 1.0 C4A A:FMN301 4.7 23.9 1.0 CD2 A:LEU169 4.8 17.3 1.0 CD2 B:TYR207 4.8 22.2 1.0 O B:HOH308 4.8 24.6 1.0 CH A:IYR302 4.8 17.1 1.0 O B:GLY125 4.9 16.8 1.0

Iodine binding site 2 out of 2 in the Crystal Structure of Mus Musculus Iodotyrosine Deiodinase (Iyd) C217A, C239A Bound to Fmn and Mono-Iodotyrosine (Mit)


Mono view


Stereo pair view

A full contact list of Iodine with other atoms in the I binding site number 2 of Crystal Structure of Mus Musculus Iodotyrosine Deiodinase (Iyd) C217A, C239A Bound to Fmn and Mono-Iodotyrosine (Mit) within 5.0Å range: probe atom residue distance (Å) B Occ B:I302 b:22.9 occ:1.00 IE B:IYR302 0.0 22.9 1.0 CE B:IYR302 2.1 18.6 1.0 CD B:IYR302 3.0 14.3 1.0 CF B:IYR302 3.1 12.3 1.0 OF B:IYR302 3.3 19.8 1.0 N A:ALA126 3.6 21.7 1.0 CA A:GLY125 3.7 14.2 1.0 CB A:TYR207 3.7 16.2 1.0 CE1 A:TYR208 3.9 15.1 1.0 CD1 A:TYR208 3.9 15.0 1.0 C A:GLY125 4.0 24.9 1.0 NE1 B:TRP165 4.0 25.4 1.0 N5 B:FMN301 4.1 18.0 1.0 CZ2 B:TRP165 4.2 16.0 1.0 C5A B:FMN301 4.3 18.8 1.0 CC B:IYR302 4.3 19.5 1.0 CG B:IYR302 4.3 15.8 1.0 CG A:TYR207 4.4 16.7 1.0 CE2 B:TRP165 4.4 24.6 1.0 CB A:ALA126 4.4 24.2 1.0 C6 B:FMN301 4.5 12.5 1.0 CA A:ALA126 4.5 19.6 1.0 OG1 B:THR235 4.6 14.3 1.0 C4A B:FMN301 4.6 20.4 1.0 CD2 B:LEU169 4.8 17.3 1.0 CD2 A:TYR207 4.8 21.8 1.0 CH B:IYR302 4.8 16.9 1.0 O A:HOH296 4.8 21.8 1.0 O A:GLY125 4.9 16.5 1.0 C9A B:FMN301 5.0 21.1 1.0

J.M.Buss, P.M.Mctamney, S.E.Rokita. Expression of A Soluble Form of Iodotyrosine Deiodinase For Active Site Characterization By Engineering the Native Membrane Protein From Mus Musculus. Protein Sci. V. 21 351 2012.
ISSN: ISSN 0961-8368
PubMed: 22238141
DOI: 10.1002/PRO.2020