Iodine in PDB 4ap2: Crystal Structure of the Human KLHL11-CUL3 Complex at 2.8A Resolution

The structure of Crystal Structure of the Human KLHL11-CUL3 Complex at 2.8A Resolution, PDB code: 4ap2 was solved by P.Canning, C.D.O.Cooper, T.Krojer, P.Filippakopoulos, V.Ayinampudi, C.H.Arrowsmith, A.M.Edwards, C.Bountra, F.Von Delft, A.N.Bullock, Structural Genomics Consortium (Sgc), with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	46.94 / 2.80
Space group	I 1 2 1
Cell size a, b, c (Å), α, β, γ (°)	147.536, 40.162, 234.758, 90.00, 107.36, 90.00
R / Rfree (%)	20.4 / 23.6

The structure of Crystal Structure of the Human KLHL11-CUL3 Complex at 2.8A Resolution also contains other interesting chemical elements:

Chlorine

(Cl)

1 atom

The binding sites of Iodine atom in the Crystal Structure of the Human KLHL11-CUL3 Complex at 2.8A Resolution (pdb code 4ap2). This binding sites where shown within 5.0 Angstroms radius around Iodine atom.
In total only one binding site of Iodine was determined in the Crystal Structure of the Human KLHL11-CUL3 Complex at 2.8A Resolution, PDB code: 4ap2:

Iodine binding site 1 out of 1 in the Crystal Structure of the Human KLHL11-CUL3 Complex at 2.8A Resolution


Mono view


Stereo pair view

A full contact list of Iodine with other atoms in the I binding site number 1 of Crystal Structure of the Human KLHL11-CUL3 Complex at 2.8A Resolution within 5.0Å range: probe atom residue distance (Å) B Occ A:I501 b:0.8 occ:1.00 OH A:TYR160 3.5 71.0 1.0 N A:ARG187 3.6 62.9 1.0 CB A:ARG187 3.8 63.2 1.0 C A:LEU185 3.8 64.2 1.0 CA A:LEU185 3.8 57.4 1.0 N A:ILE186 3.9 61.6 1.0 CE2 A:TYR160 4.0 61.2 1.0 CB A:LEU185 4.1 57.0 1.0 CG A:ARG187 4.1 76.3 1.0 CD2 A:LEU185 4.1 61.4 1.0 CA A:ARG187 4.2 63.8 1.0 N A:LEU188 4.2 63.7 1.0 CZ A:TYR160 4.2 69.0 1.0 O A:LEU185 4.4 65.0 1.0 O A:ALA118 4.5 67.3 1.0 C A:ILE186 4.6 67.2 1.0 C A:ARG187 4.7 68.2 1.0 CA A:ILE186 4.7 62.7 1.0 CG A:LEU185 4.7 60.3 1.0

P.Canning, C.D.O.Cooper, T.Krojer, J.W.Murray, A.C.W.Pike, A.Chaikuad, T.Keates, C.Thangaratnarajah, V.Hojzan, B.D.Marsden, O.Gileadi, S.Knapp, F.Von Delft, A.N.Bullock. Structural Basis For CUL3 Assembly with the Btb-Kelch Family of E3 Ubiquitin Ligases. J.Biol.Chem. V. 288 7803 2013.
ISSN: ISSN 0021-9258
PubMed: 23349464
DOI: 10.1074/JBC.M112.437996