Iodine »
PDB 442d-4dch »
4d85 »
Iodine in PDB 4d85: Crystal Structure of Human Beta Secretase in Complex with Nvp-BVI151
Enzymatic activity of Crystal Structure of Human Beta Secretase in Complex with Nvp-BVI151
All present enzymatic activity of Crystal Structure of Human Beta Secretase in Complex with Nvp-BVI151:
3.4.23.46;
3.4.23.46;
Protein crystallography data
The structure of Crystal Structure of Human Beta Secretase in Complex with Nvp-BVI151, PDB code: 4d85
was solved by
J.M.Rondeau,
E.Bourgier,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 35.05 / 2.65 |
| Space group | P 61 2 2 |
| Cell size a, b, c (Å), α, β, γ (°) | 102.656, 102.656, 170.902, 90.00, 90.00, 120.00 |
| R / Rfree (%) | n/a / n/a |
Other elements in 4d85:
The structure of Crystal Structure of Human Beta Secretase in Complex with Nvp-BVI151 also contains other interesting chemical elements:
| Fluorine | (F) | 3 atoms |
Iodine Binding Sites:
The binding sites of Iodine atom in the Crystal Structure of Human Beta Secretase in Complex with Nvp-BVI151
(pdb code 4d85). This binding sites where shown within
5.0 Angstroms radius around Iodine atom.
In total only one binding site of Iodine was determined in the Crystal Structure of Human Beta Secretase in Complex with Nvp-BVI151, PDB code: 4d85:
In total only one binding site of Iodine was determined in the Crystal Structure of Human Beta Secretase in Complex with Nvp-BVI151, PDB code: 4d85:
Iodine binding site 1 out of 1 in 4d85
Go back to
Iodine Binding Sites List in 4d85
Iodine binding site 1 out
of 1 in the Crystal Structure of Human Beta Secretase in Complex with Nvp-BVI151
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Iodine with other atoms in the I binding
site number 1 of Crystal Structure of Human Beta Secretase in Complex with Nvp-BVI151 within 5.0Å range:
|
Reference:
H.Rueeger,
R.Lueoend,
O.Rogel,
J.M.Rondeau,
H.Mobitz,
R.Machauer,
L.Jacobson,
M.Staufenbiel,
S.Desrayaud,
U.Neumann.
Discovery of Cyclic Sulfone Hydroxyethylamines As Potent and Selective Beta-Site App-Cleaving Enzyme 1 (BACE1) Inhibitors: Structure Based Design and in Vivo Reduction of Amyloid Beta-Peptides J.Med.Chem. V. 55 3364 2012.
ISSN: ISSN 0022-2623
PubMed: 22380629
DOI: 10.1021/JM300069Y
Page generated: Sun Aug 11 17:29:26 2024
ISSN: ISSN 0022-2623
PubMed: 22380629
DOI: 10.1021/JM300069Y
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