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Iodine in PDB 4dch: Insights Into Glucokinase Activation Mechanism: Observation of Multiple Distinct Protein Conformations

Enzymatic activity of Insights Into Glucokinase Activation Mechanism: Observation of Multiple Distinct Protein Conformations

All present enzymatic activity of Insights Into Glucokinase Activation Mechanism: Observation of Multiple Distinct Protein Conformations:
2.7.1.2;

Protein crystallography data

The structure of Insights Into Glucokinase Activation Mechanism: Observation of Multiple Distinct Protein Conformations, PDB code: 4dch was solved by S.E.Greasley, M.Hickey, J.Feng, E.Garcia, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 50.00 / 1.79
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 49.917, 85.794, 72.939, 90.00, 104.40, 90.00
R / Rfree (%) 19.8 / 23.1

Iodine Binding Sites:

The binding sites of Iodine atom in the Insights Into Glucokinase Activation Mechanism: Observation of Multiple Distinct Protein Conformations (pdb code 4dch). This binding sites where shown within 5.0 Angstroms radius around Iodine atom.
In total 2 binding sites of Iodine where determined in the Insights Into Glucokinase Activation Mechanism: Observation of Multiple Distinct Protein Conformations, PDB code: 4dch:
Jump to Iodine binding site number: 1; 2;

Iodine binding site 1 out of 2 in 4dch

Go back to Iodine Binding Sites List in 4dch
Iodine binding site 1 out of 2 in the Insights Into Glucokinase Activation Mechanism: Observation of Multiple Distinct Protein Conformations


Mono view


Stereo pair view

A full contact list of Iodine with other atoms in the I binding site number 1 of Insights Into Glucokinase Activation Mechanism: Observation of Multiple Distinct Protein Conformations within 5.0Å range:
probe atom residue distance (Å) B Occ
A:I503

b:21.4
occ:1.00
NZ A:LYS459 3.4 17.5 1.0
O A:HOH828 3.5 23.6 1.0
N A:ASN204 3.5 17.8 1.0
CB A:THR60 3.9 19.1 1.0
CA A:VAL203 3.9 19.9 1.0
CG2 A:THR60 4.0 21.3 1.0
CB A:VAL203 4.1 20.0 1.0
CB A:ASN204 4.2 16.7 1.0
C A:VAL203 4.3 19.1 1.0
O A:HOH960 4.3 29.7 1.0
CA A:THR60 4.3 19.4 1.0
O A:HOH816 4.3 22.3 1.0
CG2 A:VAL207 4.4 16.9 1.0
O A:THR60 4.4 18.8 1.0
CA A:ASN204 4.5 16.8 1.0
CG1 A:VAL203 4.6 19.3 1.0
O A:HOH911 4.7 30.2 1.0
CB A:VAL207 4.8 15.3 1.0
CG1 A:VAL207 4.9 15.6 1.0
C A:THR60 4.9 18.8 1.0
CE A:LYS459 4.9 17.5 1.0

Iodine binding site 2 out of 2 in 4dch

Go back to Iodine Binding Sites List in 4dch
Iodine binding site 2 out of 2 in the Insights Into Glucokinase Activation Mechanism: Observation of Multiple Distinct Protein Conformations


Mono view


Stereo pair view

A full contact list of Iodine with other atoms in the I binding site number 2 of Insights Into Glucokinase Activation Mechanism: Observation of Multiple Distinct Protein Conformations within 5.0Å range:
probe atom residue distance (Å) B Occ
A:I504

b:49.2
occ:1.00
NH2 A:ARG358 3.5 33.9 1.0
CB A:SER360 4.0 30.6 1.0
NH1 A:ARG358 4.1 33.6 1.0
CZ A:ARG358 4.3 35.3 1.0
CA A:SER360 4.7 30.5 1.0

Reference:

S.Liu, M.J.Ammirati, X.Song, J.D.Knafels, J.Zhang, S.E.Greasley, J.A.Pfefferkorn, X.Qiu. Insights Into Mechanism of Glucokinase Activation: Observation of Multiple Distinct Protein Conformations. J.Biol.Chem. V. 287 13598 2012.
ISSN: ISSN 0021-9258
PubMed: 22298776
DOI: 10.1074/JBC.M111.274126
Page generated: Sun Dec 13 19:32:16 2020

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