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Iodine in PDB 4krl: Nanobody/Vhh Domain 7D12 in Complex with Domain III of the Extracellular Region of Egfr, pH 6.0

Enzymatic activity of Nanobody/Vhh Domain 7D12 in Complex with Domain III of the Extracellular Region of Egfr, pH 6.0

All present enzymatic activity of Nanobody/Vhh Domain 7D12 in Complex with Domain III of the Extracellular Region of Egfr, pH 6.0:
2.7.10.1;

Protein crystallography data

The structure of Nanobody/Vhh Domain 7D12 in Complex with Domain III of the Extracellular Region of Egfr, pH 6.0, PDB code: 4krl was solved by K.M.Ferguson, K.R.Schmitz, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 41.79 / 2.85
Space group P 61 2 2
Cell size a, b, c (Å), α, β, γ (°) 148.048, 148.048, 82.510, 90.00, 90.00, 120.00
R / Rfree (%) 21.3 / 26.8

Iodine Binding Sites:

The binding sites of Iodine atom in the Nanobody/Vhh Domain 7D12 in Complex with Domain III of the Extracellular Region of Egfr, pH 6.0 (pdb code 4krl). This binding sites where shown within 5.0 Angstroms radius around Iodine atom.
In total only one binding site of Iodine was determined in the Nanobody/Vhh Domain 7D12 in Complex with Domain III of the Extracellular Region of Egfr, pH 6.0, PDB code: 4krl:

Iodine binding site 1 out of 1 in 4krl

Go back to Iodine Binding Sites List in 4krl
Iodine binding site 1 out of 1 in the Nanobody/Vhh Domain 7D12 in Complex with Domain III of the Extracellular Region of Egfr, pH 6.0


Mono view


Stereo pair view

A full contact list of Iodine with other atoms in the I binding site number 1 of Nanobody/Vhh Domain 7D12 in Complex with Domain III of the Extracellular Region of Egfr, pH 6.0 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:I605

b:72.0
occ:1.00
N A:HIS409 3.7 29.5 1.0
OE1 B:GLN1 3.7 48.3 1.0
CA A:GLN408 4.1 24.2 1.0
CG A:GLN408 4.3 25.2 1.0
NE2 B:GLN1 4.3 37.8 1.0
CZ A:PHE380 4.3 16.4 1.0
ND1 A:HIS409 4.4 48.8 1.0
O A:LYS407 4.4 24.1 1.0
CD B:GLN1 4.4 53.6 1.0
C A:GLN408 4.5 34.1 1.0
CE2 A:PHE380 4.6 20.0 1.0
CA A:HIS409 4.6 43.2 1.0
CB A:GLN408 4.8 13.4 1.0
CE1 A:HIS409 4.9 41.9 1.0

Reference:

K.R.Schmitz, A.Bagchi, R.C.Roovers, P.M.P.Van Bergen En Henegouwen, K.M.Ferguson. Structural Evaluation of Egfr Inhibition Mechanisms For Nanobodies/Vhh Domains. Structure V. 21 1214 2013.
ISSN: ISSN 0969-2126
PubMed: 23791944
DOI: 10.1016/J.STR.2013.05.008
Page generated: Sun Aug 11 18:29:27 2024

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