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Iodine in PDB 4mw4: Trypanosoma Brucei Methionyl-Trna Synthetase in Complex with Inhibitor 1-{3-[(5-Chloro-2-Hydroxy-3-Iodobenzyl)Amino]Propyl}-3-Thiophen-3- Ylurea (Chem 1473)Enzymatic activity of Trypanosoma Brucei Methionyl-Trna Synthetase in Complex with Inhibitor 1-{3-[(5-Chloro-2-Hydroxy-3-Iodobenzyl)Amino]Propyl}-3-Thiophen-3- Ylurea (Chem 1473)
All present enzymatic activity of Trypanosoma Brucei Methionyl-Trna Synthetase in Complex with Inhibitor 1-{3-[(5-Chloro-2-Hydroxy-3-Iodobenzyl)Amino]Propyl}-3-Thiophen-3- Ylurea (Chem 1473):
6.1.1.10; Protein crystallography data
The structure of Trypanosoma Brucei Methionyl-Trna Synthetase in Complex with Inhibitor 1-{3-[(5-Chloro-2-Hydroxy-3-Iodobenzyl)Amino]Propyl}-3-Thiophen-3- Ylurea (Chem 1473), PDB code: 4mw4
was solved by
C.Y.Koh,
J.E.Kim,
A.B.Wetzel,
W.J.De Van Der Schueren,
S.Shibata,
J.Liu,
Z.Zhang,
E.Fan,
C.L.M.J.Verlinde,
W.G.J.Hol,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 4mw4:
The structure of Trypanosoma Brucei Methionyl-Trna Synthetase in Complex with Inhibitor 1-{3-[(5-Chloro-2-Hydroxy-3-Iodobenzyl)Amino]Propyl}-3-Thiophen-3- Ylurea (Chem 1473) also contains other interesting chemical elements:
Iodine Binding Sites:
The binding sites of Iodine atom in the Trypanosoma Brucei Methionyl-Trna Synthetase in Complex with Inhibitor 1-{3-[(5-Chloro-2-Hydroxy-3-Iodobenzyl)Amino]Propyl}-3-Thiophen-3- Ylurea (Chem 1473)
(pdb code 4mw4). This binding sites where shown within
5.0 Angstroms radius around Iodine atom.
In total only one binding site of Iodine was determined in the Trypanosoma Brucei Methionyl-Trna Synthetase in Complex with Inhibitor 1-{3-[(5-Chloro-2-Hydroxy-3-Iodobenzyl)Amino]Propyl}-3-Thiophen-3- Ylurea (Chem 1473), PDB code: 4mw4: Iodine binding site 1 out of 1 in 4mw4Go back to Iodine Binding Sites List in 4mw4
Iodine binding site 1 out
of 1 in the Trypanosoma Brucei Methionyl-Trna Synthetase in Complex with Inhibitor 1-{3-[(5-Chloro-2-Hydroxy-3-Iodobenzyl)Amino]Propyl}-3-Thiophen-3- Ylurea (Chem 1473)
Mono view Stereo pair view
Reference:
C.Y.Koh,
J.E.Kim,
A.B.Wetzel,
W.J.De Van Der Schueren,
S.Shibata,
R.M.Ranade,
J.Liu,
Z.Zhang,
J.R.Gillespie,
F.S.Buckner,
C.L.Verlinde,
E.Fan,
W.G.Hol.
Structures of Trypanosoma Brucei Methionyl-Trna Synthetase with Urea-Based Inhibitors Provide Guidance For Drug Design Against Sleeping Sickness. Plos Negl Trop Dis V. 8 E2775 2014.
Page generated: Sun Dec 13 19:35:04 2020
ISSN: ISSN 1935-2727 PubMed: 24743796 DOI: 10.1371/JOURNAL.PNTD.0002775 |
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