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Atomistry » Iodine » PDB 4k1c-4mw7 » 4mw7 » |
Iodine in PDB 4mw7: Trypanosoma Brucei Methionyl-Trna Synthetase in Complex with Inhibitor 1-{3-[(5-Chloro-2-Ethoxy-3-Iodobenzyl)Amino]Propyl}-3-Thiophen-3- Ylurea (Chem 1469)Enzymatic activity of Trypanosoma Brucei Methionyl-Trna Synthetase in Complex with Inhibitor 1-{3-[(5-Chloro-2-Ethoxy-3-Iodobenzyl)Amino]Propyl}-3-Thiophen-3- Ylurea (Chem 1469)
All present enzymatic activity of Trypanosoma Brucei Methionyl-Trna Synthetase in Complex with Inhibitor 1-{3-[(5-Chloro-2-Ethoxy-3-Iodobenzyl)Amino]Propyl}-3-Thiophen-3- Ylurea (Chem 1469):
6.1.1.10; Protein crystallography data
The structure of Trypanosoma Brucei Methionyl-Trna Synthetase in Complex with Inhibitor 1-{3-[(5-Chloro-2-Ethoxy-3-Iodobenzyl)Amino]Propyl}-3-Thiophen-3- Ylurea (Chem 1469), PDB code: 4mw7
was solved by
C.Y.Koh,
J.E.Kim,
A.B.Wetzel,
W.J.De Van Der Schueren,
S.Shibata,
J.Liu,
Z.Zhang,
E.Fan,
C.L.M.J.Verlinde,
W.G.J.Hol,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 4mw7:
The structure of Trypanosoma Brucei Methionyl-Trna Synthetase in Complex with Inhibitor 1-{3-[(5-Chloro-2-Ethoxy-3-Iodobenzyl)Amino]Propyl}-3-Thiophen-3- Ylurea (Chem 1469) also contains other interesting chemical elements:
Iodine Binding Sites:
The binding sites of Iodine atom in the Trypanosoma Brucei Methionyl-Trna Synthetase in Complex with Inhibitor 1-{3-[(5-Chloro-2-Ethoxy-3-Iodobenzyl)Amino]Propyl}-3-Thiophen-3- Ylurea (Chem 1469)
(pdb code 4mw7). This binding sites where shown within
5.0 Angstroms radius around Iodine atom.
In total only one binding site of Iodine was determined in the Trypanosoma Brucei Methionyl-Trna Synthetase in Complex with Inhibitor 1-{3-[(5-Chloro-2-Ethoxy-3-Iodobenzyl)Amino]Propyl}-3-Thiophen-3- Ylurea (Chem 1469), PDB code: 4mw7: Iodine binding site 1 out of 1 in 4mw7Go back to Iodine Binding Sites List in 4mw7
Iodine binding site 1 out
of 1 in the Trypanosoma Brucei Methionyl-Trna Synthetase in Complex with Inhibitor 1-{3-[(5-Chloro-2-Ethoxy-3-Iodobenzyl)Amino]Propyl}-3-Thiophen-3- Ylurea (Chem 1469)
Mono view Stereo pair view
Reference:
C.Y.Koh,
J.E.Kim,
A.B.Wetzel,
W.J.De Van Der Schueren,
S.Shibata,
R.M.Ranade,
J.Liu,
Z.Zhang,
J.R.Gillespie,
F.S.Buckner,
C.L.Verlinde,
E.Fan,
W.G.Hol.
Structures of Trypanosoma Brucei Methionyl-Trna Synthetase with Urea-Based Inhibitors Provide Guidance For Drug Design Against Sleeping Sickness. Plos Negl Trop Dis V. 8 E2775 2014.
Page generated: Sun Aug 11 18:49:29 2024
ISSN: ISSN 1935-2727 PubMed: 24743796 DOI: 10.1371/JOURNAL.PNTD.0002775 |
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