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Atomistry » Iodine » PDB 4ttu-4xkz » 4xkx | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Iodine » PDB 4ttu-4xkz » 4xkx » |
Iodine in PDB 4xkx: Crystal Structure of BACE1 in Complex with 2-Aminooxazoline 3- Azaxanthene Inhibitor 28Enzymatic activity of Crystal Structure of BACE1 in Complex with 2-Aminooxazoline 3- Azaxanthene Inhibitor 28
All present enzymatic activity of Crystal Structure of BACE1 in Complex with 2-Aminooxazoline 3- Azaxanthene Inhibitor 28:
3.4.23.46; Protein crystallography data
The structure of Crystal Structure of BACE1 in Complex with 2-Aminooxazoline 3- Azaxanthene Inhibitor 28, PDB code: 4xkx
was solved by
D.A.Whittington,
A.M.Long,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 4xkx:
The structure of Crystal Structure of BACE1 in Complex with 2-Aminooxazoline 3- Azaxanthene Inhibitor 28 also contains other interesting chemical elements:
Iodine Binding Sites:
The binding sites of Iodine atom in the Crystal Structure of BACE1 in Complex with 2-Aminooxazoline 3- Azaxanthene Inhibitor 28
(pdb code 4xkx). This binding sites where shown within
5.0 Angstroms radius around Iodine atom.
In total 4 binding sites of Iodine where determined in the Crystal Structure of BACE1 in Complex with 2-Aminooxazoline 3- Azaxanthene Inhibitor 28, PDB code: 4xkx: Jump to Iodine binding site number: 1; 2; 3; 4; Iodine binding site 1 out of 4 in 4xkxGo back to Iodine Binding Sites List in 4xkx
Iodine binding site 1 out
of 4 in the Crystal Structure of BACE1 in Complex with 2-Aminooxazoline 3- Azaxanthene Inhibitor 28
Mono view Stereo pair view
Iodine binding site 2 out of 4 in 4xkxGo back to Iodine Binding Sites List in 4xkx
Iodine binding site 2 out
of 4 in the Crystal Structure of BACE1 in Complex with 2-Aminooxazoline 3- Azaxanthene Inhibitor 28
Mono view Stereo pair view
Iodine binding site 3 out of 4 in 4xkxGo back to Iodine Binding Sites List in 4xkx
Iodine binding site 3 out
of 4 in the Crystal Structure of BACE1 in Complex with 2-Aminooxazoline 3- Azaxanthene Inhibitor 28
Mono view Stereo pair view
Iodine binding site 4 out of 4 in 4xkxGo back to Iodine Binding Sites List in 4xkx
Iodine binding site 4 out
of 4 in the Crystal Structure of BACE1 in Complex with 2-Aminooxazoline 3- Azaxanthene Inhibitor 28
Mono view Stereo pair view
Reference:
J.J.Chen,
Q.Liu,
C.Yuan,
V.Gore,
P.Lopez,
V.Ma,
A.Amegadzie,
W.Qian,
T.C.Judd,
A.E.Minatti,
J.Brown,
Y.Cheng,
M.Xue,
W.Zhong,
T.A.Dineen,
O.Epstein,
J.Human,
C.Kreiman,
I.Marx,
M.M.Weiss,
S.A.Hitchcock,
T.S.Powers,
K.Chen,
P.H.Wen,
D.A.Whittington,
A.C.Cheng,
M.D.Bartberger,
D.Hickman,
J.A.Werner,
H.M.Vargas,
N.E.Everds,
S.L.Vonderfecht,
R.T.Dunn,
S.Wood,
R.T.Fremeau,
R.D.White,
V.F.Patel.
Development of 2-Aminooxazoline 3-Azaxanthenes As Orally Efficacious Beta-Secretase Inhibitors For the Potential Treatment of Alzheimer'S Disease. Bioorg.Med.Chem.Lett. 2015.
Page generated: Sun Aug 11 20:19:33 2024
ISSN: ESSN 1464-3405 PubMed: 25613679 DOI: 10.1016/J.BMCL.2014.12.092 |
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