Iodine in PDB 5euz: Rat Prestin Stas Domain in Complex with Iodide

The structure of Rat Prestin Stas Domain in Complex with Iodide, PDB code: 5euz was solved by G.Lolli, E.Pasqualetto, E.Costanzi, G.Bonetto, R.Battistutta, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	41.74 / 2.40
Space group	P 31 2 1
Cell size a, b, c (Å), α, β, γ (°)	61.911, 61.911, 66.490, 90.00, 90.00, 120.00
R / Rfree (%)	18.8 / 22.1

The binding sites of Iodine atom in the Rat Prestin Stas Domain in Complex with Iodide (pdb code 5euz). This binding sites where shown within 5.0 Angstroms radius around Iodine atom.
In total 4 binding sites of Iodine where determined in the Rat Prestin Stas Domain in Complex with Iodide, PDB code: 5euz:
Jump to Iodine binding site number: 1; 2; 3; 4;

Iodine binding site 1 out of 4 in the Rat Prestin Stas Domain in Complex with Iodide


Mono view


Stereo pair view

A full contact list of Iodine with other atoms in the I binding site number 1 of Rat Prestin Stas Domain in Complex with Iodide within 5.0Å range: probe atom residue distance (Å) B Occ A:I801 b:68.2 occ:1.00 H A:ILE544 2.9 62.6 1.0 HA3 A:GLY656 3.1 59.0 1.0 HG2 A:MSE652 3.2 51.5 1.0 HE3 A:MSE652 3.2 46.2 1.0 HG22 A:ILE544 3.2 66.2 1.0 HA A:MSE652 3.3 56.8 1.0 HB3 A:PRO543 3.3 66.0 1.0 HA A:PRO543 3.3 68.5 1.0 HB3 A:MSE652 3.5 54.0 1.0 N A:ILE544 3.8 52.2 1.0 H A:ASP653 3.8 52.1 1.0 HE2 A:MSE652 3.8 46.2 1.0 HE2 A:TYR545 3.9 94.3 1.0 CE A:MSE652 3.9 38.5 1.0 CG A:MSE652 3.9 42.9 1.0 CB A:MSE652 4.0 45.0 1.0 CA A:PRO543 4.0 57.1 1.0 CA A:MSE652 4.0 47.3 1.0 CA A:GLY656 4.1 49.1 1.0 CB A:PRO543 4.1 55.0 1.0 CG2 A:ILE544 4.1 55.2 1.0 HA2 A:GLY656 4.2 59.0 1.0 HB A:ILE544 4.2 66.8 1.0 C A:PRO543 4.4 53.9 1.0 O A:PHE651 4.4 36.2 1.0 HG21 A:ILE544 4.4 66.2 1.0 CE2 A:TYR545 4.5 78.6 1.0 N A:ASP653 4.5 43.4 1.0 HG11 A:VAL649 4.6 38.2 1.0 CB A:ILE544 4.6 55.7 1.0 HB2 A:PRO543 4.6 66.0 1.0 HG13 A:VAL649 4.7 38.2 1.0 HG3 A:MSE652 4.7 51.5 1.0 HE1 A:MSE652 4.7 46.2 1.0 H A:GLY656 4.7 54.3 1.0 HD2 A:TYR545 4.8 95.0 1.0 CA A:ILE544 4.8 64.2 1.0 HG23 A:ILE544 4.8 66.2 1.0 HH A:TYR545 4.8 86.5 1.0 HG3 A:PRO543 4.8 54.7 1.0 SE A:MSE652 4.8 47.0 1.0 C A:MSE652 4.9 39.5 1.0 OD1 A:ASP653 4.9 58.5 1.0 C A:GLY656 4.9 41.8 1.0 HB2 A:MSE652 4.9 54.0 1.0 N A:GLY656 4.9 45.2 1.0 CD2 A:TYR545 5.0 79.2 1.0

Iodine binding site 2 out of 4 in the Rat Prestin Stas Domain in Complex with Iodide


Mono view


Stereo pair view

A full contact list of Iodine with other atoms in the I binding site number 2 of Rat Prestin Stas Domain in Complex with Iodide within 5.0Å range: probe atom residue distance (Å) B Occ A:I802 b:69.8 occ:0.74 HA A:LYS665 3.1 64.0 1.0 HD11 A:LEU698 3.3 58.3 1.0 HB2 A:LYS665 3.5 70.5 1.0 HG12 A:VAL664 3.5 58.0 1.0 O A:HOH921 3.6 45.6 1.0 HG3 A:LYS665 3.6 82.4 1.0 CA A:LYS665 3.9 53.3 1.0 CB A:LYS665 4.0 58.8 1.0 HD21 A:LEU698 4.2 58.2 1.0 CD1 A:LEU698 4.3 48.5 1.0 H2 A:PGE810 4.3 77.4 1.0 CG A:LYS665 4.3 68.7 1.0 CG1 A:VAL664 4.4 48.3 1.0 HG11 A:VAL664 4.4 58.0 1.0 N A:LYS665 4.4 46.5 1.0 HD13 A:LEU698 4.6 58.3 1.0 HD12 A:LEU698 4.7 58.3 1.0 H A:LYS665 4.7 55.8 1.0 HD2 A:LYS665 4.8 88.0 1.0 O2 A:PGE810 4.8 63.8 1.0 C A:VAL664 4.8 50.1 1.0 O A:VAL664 4.9 41.6 1.0 HG13 A:VAL664 4.9 58.0 1.0 HB3 A:LYS665 4.9 70.5 1.0 HG2 A:LYS665 5.0 82.4 1.0

Iodine binding site 3 out of 4 in the Rat Prestin Stas Domain in Complex with Iodide


Mono view


Stereo pair view

A full contact list of Iodine with other atoms in the I binding site number 3 of Rat Prestin Stas Domain in Complex with Iodide within 5.0Å range: probe atom residue distance (Å) B Occ A:I803 b:69.8 occ:0.44 HE21 A:GLN648 2.5 69.7 1.0 NE2 A:GLN648 3.3 58.1 1.0 HG2 A:GLN648 3.4 40.5 1.0 HE22 A:GLN539 3.7 67.3 1.0 HE22 A:GLN648 3.8 69.7 1.0 CG A:GLN648 4.0 33.8 1.0 HG3 A:GLN648 4.0 40.5 1.0 CD A:GLN648 4.2 46.9 1.0 NE2 A:GLN539 4.3 56.0 1.0 HE21 A:GLN539 4.4 67.3 1.0 HG1 A:THR647 4.8 79.8 1.0

Iodine binding site 4 out of 4 in the Rat Prestin Stas Domain in Complex with Iodide


Mono view


Stereo pair view

A full contact list of Iodine with other atoms in the I binding site number 4 of Rat Prestin Stas Domain in Complex with Iodide within 5.0Å range: probe atom residue distance (Å) B Occ A:I804 b:69.8 occ:0.49 H A:ILE706 2.8 32.6 1.0 HB2 A:SER705 3.3 39.8 1.0 HG13 A:ILE706 3.4 40.3 1.0 HA A:SER705 3.4 45.0 1.0 O A:HOH928 3.5 27.6 1.0 HD12 A:ILE706 3.5 43.2 1.0 N A:ILE706 3.6 27.2 1.0 HB A:ILE706 3.7 26.6 1.0 HG21 A:THR647 3.8 35.9 1.0 O A:HOH926 3.9 50.2 1.0 CB A:SER705 4.0 33.2 1.0 CG1 A:ILE706 4.0 33.6 1.0 CA A:SER705 4.0 37.5 1.0 CD1 A:ILE706 4.1 36.0 1.0 HB3 A:SER705 4.2 39.8 1.0 CB A:ILE706 4.3 22.2 1.0 O A:HOH923 4.3 38.3 1.0 C A:SER705 4.3 32.4 1.0 HD11 A:ILE706 4.4 43.2 1.0 HG23 A:THR647 4.4 35.9 1.0 CA A:ILE706 4.6 24.2 1.0 CG2 A:THR647 4.6 29.9 1.0 H A:HIS707 4.7 34.9 1.0 HG22 A:THR647 4.9 35.9 1.0 HG12 A:ILE706 4.9 40.3 1.0 HD13 A:ILE706 5.0 43.2 1.0

G.Lolli, E.Pasqualetto, E.Costanzi, G.Bonetto, R.Battistutta. The Stas Domain of Mammalian SLC26A5 Prestin Harbours An Anion-Binding Site. Biochem.J. V. 473 365 2016.
ISSN: ESSN 1470-8728
PubMed: 26635354
DOI: 10.1042/BJ20151089