Iodine »
PDB 5kkg-5nfi »
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Iodine in PDB 5lqq: Structure of Autotaxin (ENPP2) with LM350
Enzymatic activity of Structure of Autotaxin (ENPP2) with LM350
All present enzymatic activity of Structure of Autotaxin (ENPP2) with LM350:
3.1.4.39;
3.1.4.39;
Protein crystallography data
The structure of Structure of Autotaxin (ENPP2) with LM350, PDB code: 5lqq
was solved by
W.J.Keune,
T.Heidebrecht,
E.Castelmur,
R.P.Joosten,
A.Perrakis,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 46.00 / 2.40 |
| Space group | P 1 21 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 62.655, 89.067, 77.509, 90.00, 102.88, 90.00 |
| R / Rfree (%) | 21.7 / 26.2 |
Other elements in 5lqq:
The structure of Structure of Autotaxin (ENPP2) with LM350 also contains other interesting chemical elements:
| Zinc | (Zn) | 2 atoms |
| Calcium | (Ca) | 1 atom |
| Chlorine | (Cl) | 1 atom |
| Sodium | (Na) | 1 atom |
Iodine Binding Sites:
The binding sites of Iodine atom in the Structure of Autotaxin (ENPP2) with LM350
(pdb code 5lqq). This binding sites where shown within
5.0 Angstroms radius around Iodine atom.
In total 10 binding sites of Iodine where determined in the Structure of Autotaxin (ENPP2) with LM350, PDB code: 5lqq:
Jump to Iodine binding site number: 1; 2; 3; 4; 5; 6; 7; 8; 9; 10;
In total 10 binding sites of Iodine where determined in the Structure of Autotaxin (ENPP2) with LM350, PDB code: 5lqq:
Jump to Iodine binding site number: 1; 2; 3; 4; 5; 6; 7; 8; 9; 10;
Iodine binding site 1 out of 10 in 5lqq
Go back to
Iodine Binding Sites List in 5lqq
Iodine binding site 1 out
of 10 in the Structure of Autotaxin (ENPP2) with LM350
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Iodine with other atoms in the I binding
site number 1 of Structure of Autotaxin (ENPP2) with LM350 within 5.0Å range:
|
Iodine binding site 2 out of 10 in 5lqq
Go back to
Iodine Binding Sites List in 5lqq
Iodine binding site 2 out
of 10 in the Structure of Autotaxin (ENPP2) with LM350
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Iodine with other atoms in the I binding
site number 2 of Structure of Autotaxin (ENPP2) with LM350 within 5.0Å range:
|
Iodine binding site 3 out of 10 in 5lqq
Go back to
Iodine Binding Sites List in 5lqq
Iodine binding site 3 out
of 10 in the Structure of Autotaxin (ENPP2) with LM350
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Iodine with other atoms in the I binding
site number 3 of Structure of Autotaxin (ENPP2) with LM350 within 5.0Å range:
|
Iodine binding site 4 out of 10 in 5lqq
Go back to
Iodine Binding Sites List in 5lqq
Iodine binding site 4 out
of 10 in the Structure of Autotaxin (ENPP2) with LM350
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Iodine with other atoms in the I binding
site number 4 of Structure of Autotaxin (ENPP2) with LM350 within 5.0Å range:
|
Iodine binding site 5 out of 10 in 5lqq
Go back to
Iodine Binding Sites List in 5lqq
Iodine binding site 5 out
of 10 in the Structure of Autotaxin (ENPP2) with LM350
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Iodine with other atoms in the I binding
site number 5 of Structure of Autotaxin (ENPP2) with LM350 within 5.0Å range:
|
Iodine binding site 6 out of 10 in 5lqq
Go back to
Iodine Binding Sites List in 5lqq
Iodine binding site 6 out
of 10 in the Structure of Autotaxin (ENPP2) with LM350
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Iodine with other atoms in the I binding
site number 6 of Structure of Autotaxin (ENPP2) with LM350 within 5.0Å range:
|
Iodine binding site 7 out of 10 in 5lqq
Go back to
Iodine Binding Sites List in 5lqq
Iodine binding site 7 out
of 10 in the Structure of Autotaxin (ENPP2) with LM350
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Iodine with other atoms in the I binding
site number 7 of Structure of Autotaxin (ENPP2) with LM350 within 5.0Å range:
|
Iodine binding site 8 out of 10 in 5lqq
Go back to
Iodine Binding Sites List in 5lqq
Iodine binding site 8 out
of 10 in the Structure of Autotaxin (ENPP2) with LM350
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Iodine with other atoms in the I binding
site number 8 of Structure of Autotaxin (ENPP2) with LM350 within 5.0Å range:
|
Iodine binding site 9 out of 10 in 5lqq
Go back to
Iodine Binding Sites List in 5lqq
Iodine binding site 9 out
of 10 in the Structure of Autotaxin (ENPP2) with LM350
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Iodine with other atoms in the I binding
site number 9 of Structure of Autotaxin (ENPP2) with LM350 within 5.0Å range:
|
Iodine binding site 10 out of 10 in 5lqq
Go back to
Iodine Binding Sites List in 5lqq
Iodine binding site 10 out
of 10 in the Structure of Autotaxin (ENPP2) with LM350
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Iodine with other atoms in the I binding
site number 10 of Structure of Autotaxin (ENPP2) with LM350 within 5.0Å range:
|
Reference:
L.M.Miller,
W.J.Keune,
D.Castagna,
L.C.Young,
E.L.Duffy,
F.Potjewyd,
F.Salgado-Polo,
P.Engel Garcia,
D.Semaan,
J.M.Pritchard,
A.Perrakis,
S.J.Macdonald,
C.Jamieson,
A.J.Watson.
Structure-Activity Relationships of Small Molecule Autotaxin Inhibitors with A Discrete Binding Mode. J. Med. Chem. V. 60 722 2017.
ISSN: ISSN 1520-4804
PubMed: 27982588
DOI: 10.1021/ACS.JMEDCHEM.6B01597
Page generated: Sun Aug 11 21:22:40 2024
ISSN: ISSN 1520-4804
PubMed: 27982588
DOI: 10.1021/ACS.JMEDCHEM.6B01597
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