Iodine in PDB 5lzk: Structure of the Domain of Unknown Function DUF1669 From Human FAM83B

The structure of Structure of the Domain of Unknown Function DUF1669 From Human FAM83B, PDB code: 5lzk was solved by D.M.Pinkas, J.C.Bufton, E.P.Williams, L.Shrestha, N.A.Burgess-Brown, F.Vondelft, C.H.Arrowsmith, A.M.Edwards, C.Bountra, A.Bullock, Structuralgenomics Consortium (Sgc), with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	47.83 / 1.58
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	37.498, 73.959, 63.081, 90.00, 96.19, 90.00
R / Rfree (%)	16 / 18.9

The binding sites of Iodine atom in the Structure of the Domain of Unknown Function DUF1669 From Human FAM83B (pdb code 5lzk). This binding sites where shown within 5.0 Angstroms radius around Iodine atom.
In total 4 binding sites of Iodine where determined in the Structure of the Domain of Unknown Function DUF1669 From Human FAM83B, PDB code: 5lzk:
Jump to Iodine binding site number: 1; 2; 3; 4;

Iodine binding site 1 out of 4 in the Structure of the Domain of Unknown Function DUF1669 From Human FAM83B


Mono view


Stereo pair view

A full contact list of Iodine with other atoms in the I binding site number 1 of Structure of the Domain of Unknown Function DUF1669 From Human FAM83B within 5.0Å range: probe atom residue distance (Å) B Occ A:I301 b:18.8 occ:0.59 HD2 A:LYS144 3.0 27.1 1.0 HG3 A:LYS141 3.1 18.3 1.0 HA A:LYS141 3.1 11.5 1.0 O A:HOH501 3.2 38.6 1.0 HB2 A:LYS141 3.3 14.5 1.0 O A:HOH444 3.4 15.0 1.0 CG A:LYS141 3.8 15.3 1.0 CB A:LYS141 3.8 12.1 1.0 CA A:LYS141 3.8 9.6 1.0 CD A:LYS144 3.9 22.6 1.0 HD2 A:LYS141 4.0 33.4 1.0 HE3 A:LYS144 4.1 28.6 1.0 HD3 A:LYS144 4.2 27.1 1.0 HB2 A:LYS144 4.3 17.3 1.0 HE2 A:LYS141 4.4 44.9 1.0 CD A:LYS141 4.4 27.8 1.0 N A:LYS141 4.4 11.1 1.0 CE A:LYS144 4.5 23.9 1.0 HE2 A:LYS144 4.6 28.6 1.0 HG2 A:LYS141 4.6 18.3 1.0 H A:LYS141 4.6 13.4 1.0 HB3 A:LYS141 4.7 14.5 1.0 CE A:LYS141 5.0 37.4 1.0 CG A:LYS144 5.0 13.4 1.0 CB A:LYS144 5.0 14.4 1.0

Iodine binding site 2 out of 4 in the Structure of the Domain of Unknown Function DUF1669 From Human FAM83B


Mono view


Stereo pair view

A full contact list of Iodine with other atoms in the I binding site number 2 of Structure of the Domain of Unknown Function DUF1669 From Human FAM83B within 5.0Å range: probe atom residue distance (Å) B Occ A:I302 b:61.2 occ:0.59 HE2 A:HIS254 2.6 21.9 1.0 OG A:SER249 3.3 21.2 1.0 HE2 A:MET247 3.3 15.6 1.0 NE2 A:HIS254 3.5 18.3 1.0 HG A:SER249 3.7 25.5 1.0 HE1 A:MET247 3.7 15.6 1.0 HB2 A:SER249 3.8 24.3 1.0 HB3 A:SER249 3.8 24.3 1.0 O B:HOH409 3.9 43.0 1.0 CB A:SER249 3.9 20.3 1.0 CE A:MET247 3.9 13.0 1.0 CE1 A:HIS254 4.4 19.8 1.0 HE1 A:HIS254 4.4 23.8 1.0 CD2 A:HIS254 4.4 19.4 1.0 HE1 A:PHE250 4.5 19.7 1.0 HD2 A:HIS254 4.5 23.3 1.0 SD A:MET247 4.6 27.9 1.0 HE3 A:MET247 4.8 15.6 1.0 HG3 A:MET247 5.0 26.6 1.0

Iodine binding site 3 out of 4 in the Structure of the Domain of Unknown Function DUF1669 From Human FAM83B


Mono view


Stereo pair view

A full contact list of Iodine with other atoms in the I binding site number 3 of Structure of the Domain of Unknown Function DUF1669 From Human FAM83B within 5.0Å range: probe atom residue distance (Å) B Occ A:I303 b:77.4 occ:0.61 HE2 A:PHE163 3.4 24.6 1.0 HG21 A:VAL167 3.5 21.6 1.0 HB2 A:CYS197 3.6 37.1 1.0 HG11 A:VAL167 3.9 27.0 1.0 HD2 A:PHE163 3.9 27.6 1.0 HA A:LYS164 4.0 17.3 1.0 CE2 A:PHE163 4.0 20.5 1.0 HB3 A:GLN195 4.1 32.8 1.0 HG A:CYS197 4.2 42.5 1.0 O A:HOH542 4.3 41.8 1.0 HB A:VAL167 4.3 21.8 1.0 HB2 A:LYS164 4.3 22.4 1.0 CD2 A:PHE163 4.3 23.0 1.0 CB A:CYS197 4.4 30.9 1.0 CG2 A:VAL167 4.4 18.0 1.0 HB3 A:CYS197 4.6 37.1 1.0 CB A:VAL167 4.7 18.2 1.0 SG A:CYS197 4.7 35.5 1.0 HG23 A:VAL167 4.7 21.6 1.0 CG1 A:VAL167 4.7 22.5 1.0 CA A:LYS164 4.8 14.4 1.0 HE21 A:GLN195 4.8 46.1 1.0 HB2 A:GLN195 4.9 32.8 1.0 CB A:LYS164 4.9 18.7 1.0 CB A:GLN195 5.0 27.4 1.0

Iodine binding site 4 out of 4 in the Structure of the Domain of Unknown Function DUF1669 From Human FAM83B


Mono view


Stereo pair view

A full contact list of Iodine with other atoms in the I binding site number 4 of Structure of the Domain of Unknown Function DUF1669 From Human FAM83B within 5.0Å range: probe atom residue distance (Å) B Occ A:I304 b:19.0 occ:0.58 H A:VAL282 2.7 20.2 1.0 HA A:CYS281 3.2 19.8 1.0 HB3 A:CYS281 3.3 16.5 1.0 HG23 A:VAL282 3.4 23.6 1.0 N A:VAL282 3.5 16.8 1.0 HH22 A:ARG208 3.5 17.4 1.0 O A:HOH460 3.6 41.4 1.0 HB A:VAL282 3.7 22.4 1.0 CA A:CYS281 3.8 16.5 1.0 CB A:CYS281 3.9 13.8 1.0 NH2 A:ARG208 4.1 14.5 1.0 C A:CYS281 4.2 16.0 1.0 CG2 A:VAL282 4.2 19.7 1.0 HH21 A:ARG208 4.3 17.4 1.0 SG A:CYS281 4.3 21.4 1.0 CB A:VAL282 4.3 18.7 1.0 HG21 A:VAL282 4.5 23.6 1.0 CA A:VAL282 4.5 14.6 1.0 HH12 A:ARG208 4.8 17.6 1.0 HB2 A:CYS281 4.8 16.5 1.0 HG A:CYS281 4.8 25.7 1.0 CZ A:ARG208 5.0 16.3 1.0 O A:VAL282 5.0 18.0 1.0 HG22 A:VAL282 5.0 23.6 1.0

D.M.Pinkas, J.C.Bufton, E.P.Williams, L.Shrestha, N.A.Burgess-Brown, F.Von Delft, C.H.Arrowsmith, A.M.Edwards, C.Bountra, A.Bullock. Structure of the Domain of Unknown Function DUF1669 From Human FAM83B To Be Published.