Iodine in PDB 5zqf: Crystal Structure of Human Topoisomerase II Beta in Complex with 5- Iodouridine-Containing-Dna in Space Group P3221

Enzymatic activity of Crystal Structure of Human Topoisomerase II Beta in Complex with 5- Iodouridine-Containing-Dna in Space Group P3221

All present enzymatic activity of Crystal Structure of Human Topoisomerase II Beta in Complex with 5- Iodouridine-Containing-Dna in Space Group P3221:
5.99.1.3;

Protein crystallography data

The structure of Crystal Structure of Human Topoisomerase II Beta in Complex with 5- Iodouridine-Containing-Dna in Space Group P3221, PDB code: 5zqf was solved by S.F.Chen, Y.R.Wang, N.L.Chan, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

*Resolution Low / High (Å)*	19.90 / 3.87
*Space group*	P 3₂ 2 1
*Cell size a, b, c (Å), α, β, γ (°)*	94.990, 94.990, 231.486, 90.00, 90.00, 120.00
*R / R_free (%)*	20.3 / 24.7

Other elements in 5zqf:

The structure of Crystal Structure of Human Topoisomerase II Beta in Complex with 5- Iodouridine-Containing-Dna in Space Group P3221 also contains other interesting chemical elements:

Manganese

(Mn)

2 atoms

Iodine Binding Sites:

The binding sites of Iodine atom in the Crystal Structure of Human Topoisomerase II Beta in Complex with 5- Iodouridine-Containing-Dna in Space Group P3221 (pdb code 5zqf). This binding sites where shown within 5.0 Angstroms radius around Iodine atom.
In total 2 binding sites of Iodine where determined in the Crystal Structure of Human Topoisomerase II Beta in Complex with 5- Iodouridine-Containing-Dna in Space Group P3221, PDB code: 5zqf:
Jump to Iodine binding site number: 1; 2;

Iodine binding site 1 out of 2 in 5zqf

Go back to

Iodine Binding Sites List in 5zqf

Iodine binding site 1 out of 2 in the Crystal Structure of Human Topoisomerase II Beta in Complex with 5- Iodouridine-Containing-Dna in Space Group P3221

Mono view

Stereo pair view

A full contact list of Iodine with other atoms in the I binding site number 1 of Crystal Structure of Human Topoisomerase II Beta in Complex with 5- Iodouridine-Containing-Dna in Space Group P3221 within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
C:I15 b:0.1 occ:1.00	I5	C:IU15	0.0	0.1	1.0
	C5	C:IU15	2.1	0.0	1.0
	C4	C:IU15	3.2	0.3	1.0
	C6	C:IU15	3.2	0.3	1.0
	O4	C:IU15	3.3	0.3	1.0
	N4	C:DC16	3.7	0.4	1.0
	C6	C:DC14	3.9	0.2	1.0
	OP2	C:IU15	4.0	91.3	1.0
	C5	C:DC14	4.0	0.5	1.0
	N1	C:DC14	4.3	0.6	1.0
	C2'	C:DC14	4.4	0.2	1.0
	C4	C:DC14	4.4	0.9	1.0
	N3	C:IU15	4.5	0.3	1.0
	N1	C:IU15	4.5	0.3	1.0
	C3'	C:DC14	4.6	0.5	1.0
	C4	C:DC16	4.7	0.9	1.0
	O6	B:DG5	4.7	0.3	1.0
	C2	C:DC14	4.7	0.6	1.0
	N3	C:DC14	4.8	0.7	1.0
	C1'	C:DC14	4.9	0.9	1.0

Iodine binding site 2 out of 2 in 5zqf

Go back to

Iodine Binding Sites List in 5zqf

Iodine binding site 2 out of 2 in the Crystal Structure of Human Topoisomerase II Beta in Complex with 5- Iodouridine-Containing-Dna in Space Group P3221

Mono view

Stereo pair view

A full contact list of Iodine with other atoms in the I binding site number 2 of Crystal Structure of Human Topoisomerase II Beta in Complex with 5- Iodouridine-Containing-Dna in Space Group P3221 within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
C:I20 b:0.3 occ:1.00	I5	C:IU20	0.0	0.3	1.0
	C5	C:IU20	2.1	0.5	1.0
	C6	C:IU20	3.1	0.2	1.0
	C4	C:IU20	3.2	0.9	1.0
	O4	C:IU20	3.3	0.6	1.0
	C2'	C:DC19	4.1	0.3	1.0
	C6	C:DC19	4.2	0.6	1.0
	C5	C:DC19	4.4	0.6	1.0
	N1	C:DC19	4.5	0.9	1.0
	N1	C:IU20	4.5	0.6	1.0
	N3	C:IU20	4.5	0.9	1.0
	C1'	C:DC19	4.9	0.6	1.0
	C4	C:DC19	4.9	0.7	1.0
	C2	C:DC19	5.0	0.0	1.0

Reference:

S.F.Chen, N.L.Huang, J.H.Lin, C.C.Wu, Y.R.Wang, Y.J.Yu, M.K.Gilson, N.L.Chan. Structural Insights Into the Gating of Dna Passage By the Topoisomerase II Dna-Gate. Nat Commun V. 9 3085 2018.
ISSN: ESSN 2041-1723
PubMed: 30082834
DOI: 10.1038/S41467-018-05406-Y

Page generated: Sun Aug 11 22:28:05 2024

Last articles

Zn in 9JPJ
Zn in 9JP7
Zn in 9JPK
Zn in 9JPL
Zn in 9GN6
Zn in 9GN7
Zn in 9GKU
Zn in 9GKW
Zn in 9GKX
Zn in 9GL0

	© Copyright 2008-2020 by atomistry.com
Home \| Site Map \| Copyright \| Contact us \| Privacy