Iodine in PDB 6sq4: Crystal Structure of Mouse PRMT6 in Complex with Inhibitor U2

All present enzymatic activity of Crystal Structure of Mouse PRMT6 in Complex with Inhibitor U2:
2.1.1.319;

The structure of Crystal Structure of Mouse PRMT6 in Complex with Inhibitor U2, PDB code: 6sq4 was solved by L.Bonnefond, J.Cavarelli, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	35.06 / 1.70
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	41.950, 118.101, 72.093, 90.00, 103.45, 90.00
R / Rfree (%)	18.1 / 21.1

The binding sites of Iodine atom in the Crystal Structure of Mouse PRMT6 in Complex with Inhibitor U2 (pdb code 6sq4). This binding sites where shown within 5.0 Angstroms radius around Iodine atom.
In total 2 binding sites of Iodine where determined in the Crystal Structure of Mouse PRMT6 in Complex with Inhibitor U2, PDB code: 6sq4:
Jump to Iodine binding site number: 1; 2;

Iodine binding site 1 out of 2 in the Crystal Structure of Mouse PRMT6 in Complex with Inhibitor U2


Mono view


Stereo pair view

A full contact list of Iodine with other atoms in the I binding site number 1 of Crystal Structure of Mouse PRMT6 in Complex with Inhibitor U2 within 5.0Å range: probe atom residue distance (Å) B Occ A:I401 b:32.6 occ:1.00 HD3 A:LYS215 3.3 28.3 1.0 HA A:GLN216 3.4 29.5 1.0 HG2 A:LYS215 3.5 27.5 1.0 HB3 A:GLN216 3.6 34.7 1.0 HB3 A:LYS215 3.7 23.8 1.0 CD A:LYS215 4.1 23.6 1.0 CA A:GLN216 4.1 24.6 1.0 CG A:LYS215 4.1 22.9 1.0 N A:GLN216 4.2 21.8 1.0 O A:HOH633 4.2 21.1 1.0 HE2 A:LYS215 4.2 34.2 1.0 CB A:GLN216 4.3 28.9 1.0 CB A:LYS215 4.4 19.9 1.0 H A:GLN216 4.4 26.2 1.0 C A:LYS215 4.4 20.3 1.0 O A:LYS215 4.6 21.0 1.0 HB2 A:GLN216 4.7 34.7 1.0 CE A:LYS215 4.7 28.4 1.0 HD2 A:LYS215 4.8 28.3 1.0 O A:HOH624 4.9 31.4 1.0 HZ3 A:LYS215 4.9 36.0 1.0

Iodine binding site 2 out of 2 in the Crystal Structure of Mouse PRMT6 in Complex with Inhibitor U2


Mono view


Stereo pair view

A full contact list of Iodine with other atoms in the I binding site number 2 of Crystal Structure of Mouse PRMT6 in Complex with Inhibitor U2 within 5.0Å range: probe atom residue distance (Å) B Occ B:I401 b:30.9 occ:1.00 HG2 B:GLU260 3.4 50.2 1.0 HG3 B:ARG263 3.7 55.4 1.0 HB2 B:ARG263 3.9 47.8 1.0 HB3 B:GLU260 4.0 38.8 1.0 HA B:ARG263 4.1 45.2 1.0 HE B:ARG263 4.3 66.5 1.0 CG B:GLU260 4.3 41.8 1.0 CB B:ARG263 4.5 39.8 1.0 CG B:ARG263 4.5 46.1 1.0 HG3 B:GLU260 4.6 50.2 1.0 CB B:GLU260 4.6 32.4 1.0 HB3 B:ALA262 4.7 33.4 1.0 CA B:ARG263 4.7 37.6 1.0 HB2 B:GLU260 4.8 38.8 1.0 NE B:ARG263 4.9 55.4 1.0 N B:ARG263 5.0 31.1 1.0 H B:ARG263 5.0 37.3 1.0

L.Bonnefond, J.Cavarelli. Crystal Structure of Mouse PRMT6 in Complex with Inhibitors To Be Published.