Atomistry » Iodine » PDB 7ben-7fgj » 7cd0
Atomistry »
  Iodine »
    PDB 7ben-7fgj »
      7cd0 »

Iodine in PDB 7cd0: Crystal Structure of the 2-Iodoporphobilinogen-Bound ES2 Intermediate Form of Human Hydroxymethylbilane Synthase

Enzymatic activity of Crystal Structure of the 2-Iodoporphobilinogen-Bound ES2 Intermediate Form of Human Hydroxymethylbilane Synthase

All present enzymatic activity of Crystal Structure of the 2-Iodoporphobilinogen-Bound ES2 Intermediate Form of Human Hydroxymethylbilane Synthase:
2.5.1.61;

Protein crystallography data

The structure of Crystal Structure of the 2-Iodoporphobilinogen-Bound ES2 Intermediate Form of Human Hydroxymethylbilane Synthase, PDB code: 7cd0 was solved by H.Sato, M.Sugishima, K.Wada, K.Hirabayashi, M.Tsukaguchi, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 45.25 / 2.31
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 81.416, 81.366, 108.85, 90, 90, 90
R / Rfree (%) 22.7 / 27.7

Iodine Binding Sites:

The binding sites of Iodine atom in the Crystal Structure of the 2-Iodoporphobilinogen-Bound ES2 Intermediate Form of Human Hydroxymethylbilane Synthase (pdb code 7cd0). This binding sites where shown within 5.0 Angstroms radius around Iodine atom.
In total only one binding site of Iodine was determined in the Crystal Structure of the 2-Iodoporphobilinogen-Bound ES2 Intermediate Form of Human Hydroxymethylbilane Synthase, PDB code: 7cd0:

Iodine binding site 1 out of 1 in 7cd0

Go back to Iodine Binding Sites List in 7cd0
Iodine binding site 1 out of 1 in the Crystal Structure of the 2-Iodoporphobilinogen-Bound ES2 Intermediate Form of Human Hydroxymethylbilane Synthase


Mono view


Stereo pair view

A full contact list of Iodine with other atoms in the I binding site number 1 of Crystal Structure of the 2-Iodoporphobilinogen-Bound ES2 Intermediate Form of Human Hydroxymethylbilane Synthase within 5.0Å range:
probe atom residue distance (Å) B Occ
B:I402

b:107.9
occ:0.74
 I4A B:FWL402 0.0 107.9 0.7
C4A B:FWL402 2.1 65.3 0.7
NA B:FWL402 3.1 64.2 0.7
C3A B:FWL402 3.2 61.6 0.7
C7A B:FWL402 3.7 61.8 0.7
C8A B:FWL402 3.8 65.6 0.7
OD2 B:ASP99 3.9 49.3 1.0
OD1 B:ASP99 4.2 54.4 1.0
CG B:ASP99 4.2 52.9 1.0
C1A B:FWL402 4.2 58.6 0.7
C21 B:7J8401 4.3 52.8 1.0
C2A B:FWL402 4.4 59.5 0.7
N B:7J8401 4.8 53.0 1.0
O12 B:7J8401 4.8 65.4 1.0
C22 B:7J8401 4.8 53.1 1.0
NH2 B:ARG26 4.8 73.6 1.0
C9A B:FWL402 4.9 65.5 0.7

Reference:

H.Sato, M.Sugishima, M.Tsukaguchi, T.Masuko, M.Iijima, M.Takano, Y.Omata, K.Hirabayashi, K.Wada, Y.Hisaeda, K.Yamamoto. Crystal Structures of Hydroxymethylbilane Synthase Complexed with A Substrate Analog: A Single Substrate-Binding Site For Four Consecutive Condensation Steps. Biochem.J. V. 478 1023 2021.
ISSN: ESSN 1470-8728
PubMed: 33600566
DOI: 10.1042/BCJ20200996
Page generated: Mon Aug 12 00:55:03 2024

Last articles

Zn in 9JYW
Zn in 9IR4
Zn in 9IR3
Zn in 9GMX
Zn in 9GMW
Zn in 9JEJ
Zn in 9ERF
Zn in 9ERE
Zn in 9EGV
Zn in 9EGW
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy