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Iodine in PDB 7juy: Crystal Structure of KSR1:MEK1 in Complex with Amp-Pnp, and Allosteric Mek Inhibitor CobimetinibEnzymatic activity of Crystal Structure of KSR1:MEK1 in Complex with Amp-Pnp, and Allosteric Mek Inhibitor Cobimetinib
All present enzymatic activity of Crystal Structure of KSR1:MEK1 in Complex with Amp-Pnp, and Allosteric Mek Inhibitor Cobimetinib:
2.7.11.1; 2.7.12.2; Protein crystallography data
The structure of Crystal Structure of KSR1:MEK1 in Complex with Amp-Pnp, and Allosteric Mek Inhibitor Cobimetinib, PDB code: 7juy
was solved by
Z.M.Khan,
A.C.Dar,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 7juy:
The structure of Crystal Structure of KSR1:MEK1 in Complex with Amp-Pnp, and Allosteric Mek Inhibitor Cobimetinib also contains other interesting chemical elements:
Iodine Binding Sites:
The binding sites of Iodine atom in the Crystal Structure of KSR1:MEK1 in Complex with Amp-Pnp, and Allosteric Mek Inhibitor Cobimetinib
(pdb code 7juy). This binding sites where shown within
5.0 Angstroms radius around Iodine atom.
In total only one binding site of Iodine was determined in the Crystal Structure of KSR1:MEK1 in Complex with Amp-Pnp, and Allosteric Mek Inhibitor Cobimetinib, PDB code: 7juy: Iodine binding site 1 out of 1 in 7juyGo back to Iodine Binding Sites List in 7juy
Iodine binding site 1 out
of 1 in the Crystal Structure of KSR1:MEK1 in Complex with Amp-Pnp, and Allosteric Mek Inhibitor Cobimetinib
Mono view Stereo pair view
Reference:
Z.M.Khan,
A.M.Real,
W.M.Marsiglia,
A.Chow,
M.E.Duffy,
J.R.Yerabolu,
A.P.Scopton,
A.C.Dar.
Structural Basis For the Action of the Drug Trametinib at Ksr-Bound Mek. Nature 2020.
Page generated: Sun Dec 13 20:02:12 2020
ISSN: ESSN 1476-4687 PubMed: 32927473 DOI: 10.1038/S41586-020-2760-4 |
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