Iodine in PDB 7m0y: Crystal Structure of the Braf:MEK1 Kinases in Complex with Amppnp and Trametinib

Enzymatic activity of Crystal Structure of the Braf:MEK1 Kinases in Complex with Amppnp and Trametinib

All present enzymatic activity of Crystal Structure of the Braf:MEK1 Kinases in Complex with Amppnp and Trametinib:
2.7.11.1; 2.7.12.2;

Protein crystallography data

The structure of Crystal Structure of the Braf:MEK1 Kinases in Complex with Amppnp and Trametinib, PDB code: 7m0y was solved by K.Li, G.Gonzalez Del-Pino, B.H.Ha, E.Park, M.J.Eck, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

*Resolution Low / High (Å)*	47.08 / 3.45
*Space group*	P 3₁ 2 1
*Cell size a, b, c (Å), α, β, γ (°)*	116.716, 116.716, 129.483, 90, 90, 120
*R / R_free (%)*	19.5 / 21.8

Other elements in 7m0y:

The structure of Crystal Structure of the Braf:MEK1 Kinases in Complex with Amppnp and Trametinib also contains other interesting chemical elements:

Magnesium	(Mg)	2 atoms
Fluorine	(F)	1 atom

Iodine Binding Sites:

The binding sites of Iodine atom in the Crystal Structure of the Braf:MEK1 Kinases in Complex with Amppnp and Trametinib (pdb code 7m0y). This binding sites where shown within 5.0 Angstroms radius around Iodine atom.
In total only one binding site of Iodine was determined in the Crystal Structure of the Braf:MEK1 Kinases in Complex with Amppnp and Trametinib, PDB code: 7m0y:

Iodine binding site 1 out of 1 in 7m0y

Go back to

Iodine Binding Sites List in 7m0y

Iodine binding site 1 out of 1 in the Crystal Structure of the Braf:MEK1 Kinases in Complex with Amppnp and Trametinib

Mono view

Stereo pair view

A full contact list of Iodine with other atoms in the I binding site number 1 of Crystal Structure of the Braf:MEK1 Kinases in Complex with Amppnp and Trametinib within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
B:I404 b:92.2 occ:1.00	I17	B:QOM404	0.0	92.2	1.0
	C14	B:QOM404	2.1	77.4	1.0
	C15	B:QOM404	3.0	65.3	1.0
	C13	B:QOM404	3.1	82.1	1.0
	O	B:VAL127	3.3	70.2	1.0
	CE1	B:PHE209	4.1	64.1	1.0
	CB	B:VAL127	4.1	51.4	1.0
	C	B:VAL127	4.2	62.1	1.0
	C16	B:QOM404	4.3	67.8	1.0
	CZ	B:PHE209	4.4	69.4	1.0
	C12	B:QOM404	4.4	79.0	1.0
	CG2	B:ILE126	4.6	61.2	1.0
	CA	B:VAL127	4.6	54.0	1.0
	CB	B:PHE129	4.6	68.3	1.0
	CG1	B:VAL127	4.6	56.1	1.0
	N	B:VAL127	4.7	61.5	1.0
	O	B:GLY128	4.7	61.8	1.0
	CD2	B:LEU118	4.7	53.9	1.0
	CD1	B:LEU118	4.7	53.9	1.0
	SG	B:CYS207	4.9	90.5	1.0
	SD	B:MET143	4.9	58.6	1.0
	C	B:GLY128	4.9	66.0	1.0
	C11	B:QOM404	4.9	68.3	1.0
	CB	B:MET143	4.9	61.1	1.0
	CD1	B:PHE209	4.9	64.5	1.0

Reference:

K.Li, G.Gonzalez Del-Pino, B.H.Ha, E.Park, M.J.Eck. Crystal Structure of the Braf:MEK1 Kinases in Complex with Amppnp and Binimetinib To Be Published.

Page generated: Mon Aug 12 01:44:33 2024

Last articles

Zn in 9J0N
Zn in 9J0O
Zn in 9J0P
Zn in 9FJX
Zn in 9EKB
Zn in 9C0F
Zn in 9CAH
Zn in 9CH0
Zn in 9CH3
Zn in 9CH1

	© Copyright 2008-2020 by atomistry.com
Home \| Site Map \| Copyright \| Contact us \| Privacy