Iodine in PDB 7mn0: N74D Mutant of the Hiv-1 Capsid Protein

The structure of N74D Mutant of the Hiv-1 Capsid Protein, PDB code: 7mn0 was solved by A.T.Gres, K.A.Kirby, S.G.Sarafianos, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	45.87 / 2.90
Space group	P 6
Cell size a, b, c (Å), α, β, γ (°)	91.741, 91.741, 57.163, 90, 90, 120
R / Rfree (%)	21.9 / 27.4

The binding sites of Iodine atom in the N74D Mutant of the Hiv-1 Capsid Protein (pdb code 7mn0). This binding sites where shown within 5.0 Angstroms radius around Iodine atom.
In total 6 binding sites of Iodine where determined in the N74D Mutant of the Hiv-1 Capsid Protein, PDB code: 7mn0:
Jump to Iodine binding site number: 1; 2; 3; 4; 5; 6;

Iodine binding site 1 out of 6 in the N74D Mutant of the Hiv-1 Capsid Protein


Mono view


Stereo pair view

A full contact list of Iodine with other atoms in the I binding site number 1 of N74D Mutant of the Hiv-1 Capsid Protein within 5.0Å range: probe atom residue distance (Å) B Occ A:I300 b:101.3 occ:0.43 CD A:ARG18 3.2 108.9 1.0 CG A:ARG18 3.8 100.0 1.0 NE A:ARG18 4.4 113.8 1.0 NH1 A:ARG18 4.7 115.4 1.0 CZ A:ARG18 4.9 113.5 1.0

Iodine binding site 2 out of 6 in the N74D Mutant of the Hiv-1 Capsid Protein


Mono view


Stereo pair view

A full contact list of Iodine with other atoms in the I binding site number 2 of N74D Mutant of the Hiv-1 Capsid Protein within 5.0Å range: probe atom residue distance (Å) B Occ A:I301 b:94.0 occ:0.43 NH2 A:ARG18 3.1 103.2 1.0 NE A:ARG18 3.9 113.8 1.0 CZ A:ARG18 3.9 113.5 1.0 CB A:ALA22 4.6 77.9 1.0 O A:ARG18 4.9 84.9 1.0

Iodine binding site 3 out of 6 in the N74D Mutant of the Hiv-1 Capsid Protein


Mono view


Stereo pair view

A full contact list of Iodine with other atoms in the I binding site number 3 of N74D Mutant of the Hiv-1 Capsid Protein within 5.0Å range: probe atom residue distance (Å) B Occ A:I302 b:63.2 occ:0.55 NH1 A:ARG173 3.7 59.7 1.0 CD A:ARG173 3.9 61.5 1.0 OE1 A:GLU35 3.9 82.4 1.0 CG A:LYS170 4.1 87.8 1.0 CB A:PRO34 4.2 66.3 1.0 CG A:PRO34 4.3 61.8 1.0 NZ A:LYS170 4.5 104.4 1.0 CA A:LYS170 4.6 75.4 1.0 CZ A:ARG173 4.6 61.4 1.0 CD A:PRO34 4.7 62.0 1.0 CB A:LYS170 4.7 85.5 1.0 NE A:ARG173 4.7 64.0 1.0 O A:LYS170 4.8 59.3 1.0 CB A:ARG173 4.9 61.1 1.0 CG A:ARG173 5.0 62.2 1.0 CD A:GLU35 5.0 80.8 1.0

Iodine binding site 4 out of 6 in the N74D Mutant of the Hiv-1 Capsid Protein


Mono view


Stereo pair view

A full contact list of Iodine with other atoms in the I binding site number 4 of N74D Mutant of the Hiv-1 Capsid Protein within 5.0Å range: probe atom residue distance (Å) B Occ A:I303 b:87.6 occ:0.44 CA A:PRO38 3.5 65.9 1.0 CB A:SER41 3.8 68.2 1.0 N A:PRO38 3.8 68.3 1.0 O A:ILE37 4.0 50.0 1.0 CG2 A:ILE37 4.0 79.3 1.0 C A:ILE37 4.0 58.5 1.0 CB A:PRO38 4.1 60.8 1.0 CG A:PRO38 4.3 67.0 1.0 OG A:SER41 4.3 75.0 1.0 CD A:PRO38 4.4 68.0 1.0 C A:PRO38 4.7 61.7 1.0 CD1 A:ILE135 4.7 85.7 1.0 CB A:ILE37 4.9 75.5 1.0 O A:PRO38 4.9 55.3 1.0

Iodine binding site 5 out of 6 in the N74D Mutant of the Hiv-1 Capsid Protein


Mono view


Stereo pair view

A full contact list of Iodine with other atoms in the I binding site number 5 of N74D Mutant of the Hiv-1 Capsid Protein within 5.0Å range: probe atom residue distance (Å) B Occ A:I304 b:57.9 occ:0.53 CB A:GLN95 3.6 110.2 1.0 N A:ALA92 3.8 113.0 1.0 CG A:GLN95 3.8 107.9 1.0 CA A:ILE91 4.1 107.2 1.0 O A:PRO90 4.4 113.6 1.0 CB A:ALA92 4.5 119.1 1.0 C A:ILE91 4.5 105.5 1.0 CG2 A:ILE91 4.5 112.6 1.0 CD A:GLN95 4.5 110.8 1.0 CD1 A:ILE91 4.6 109.6 1.0 CA A:ALA92 4.8 117.2 1.0 CB A:ILE91 4.9 108.3 1.0 OE1 A:GLN95 5.0 115.7 1.0

Iodine binding site 6 out of 6 in the N74D Mutant of the Hiv-1 Capsid Protein


Mono view


Stereo pair view

A full contact list of Iodine with other atoms in the I binding site number 6 of N74D Mutant of the Hiv-1 Capsid Protein within 5.0Å range: probe atom residue distance (Å) B Occ A:I305 b:94.8 occ:0.53 SD A:MET144 3.5 91.0 1.0 CG A:MET144 3.6 95.0 1.0 CE1 A:TYR145 4.1 108.0 1.0 CD1 A:TYR145 4.5 111.1 1.0 CZ A:TYR145 4.9 106.1 1.0 O A:MET144 4.9 98.1 1.0 CE A:MET144 5.0 99.2 1.0

A.Selyutina, L.M.Simons, K.A.Kirby, A.Bulnes-Ramos, P.Hu, S.G.Sarafianos, J.F.Hultquist, F.Diaz-Griffero. TRIM5ALPHA Restriction of Hiv-1-N74D Viruses in Lymphocytes Is Caused By A Loss of Cyclophilin A Protection. Viruses V. 14 363 2022.
ISSN: ESSN 1999-4915
PubMed: 35215956
DOI: 10.3390/V14020363