Iodine in PDB 7qtq: Structure of Native, Iodinated Bovine Thyroglobulin Solved on Strepavidin Affinity Grids.

The binding sites of Iodine atom in the Structure of Native, Iodinated Bovine Thyroglobulin Solved on Strepavidin Affinity Grids. (pdb code 7qtq). This binding sites where shown within 5.0 Angstroms radius around Iodine atom.
In total 8 binding sites of Iodine where determined in the Structure of Native, Iodinated Bovine Thyroglobulin Solved on Strepavidin Affinity Grids., PDB code: 7qtq:
Jump to Iodine binding site number: 1; 2; 3; 4; 5; 6; 7; 8;

Iodine binding site 1 out of 8 in the Structure of Native, Iodinated Bovine Thyroglobulin Solved on Strepavidin Affinity Grids.


Mono view


Stereo pair view

A full contact list of Iodine with other atoms in the I binding site number 1 of Structure of Native, Iodinated Bovine Thyroglobulin Solved on Strepavidin Affinity Grids. within 5.0Å range: probe atom residue distance (Å) B Occ A:I2573 b:107.5 occ:1.00 I3 A:T442573 0.0 107.5 1.0 C3 A:T442573 2.1 107.5 1.0 HE2 A:PHE2576 2.9 62.0 1.0 C2 A:T442573 3.0 107.5 1.0 C4 A:T442573 3.0 107.5 1.0 O4 A:T442573 3.2 107.5 1.0 HB2 A:ALA2542 3.4 56.1 1.0 HB3 A:ALA2542 3.4 56.1 1.0 C2' A:T442573 3.6 107.5 1.0 C1' A:T442573 3.7 107.5 1.0 CE2 A:PHE2576 3.7 62.0 1.0 CB A:ALA2542 3.7 56.1 1.0 HB1 A:ALA2542 3.8 56.1 1.0 HA A:PHE2539 3.9 74.6 1.0 HD2 A:PHE2576 3.9 62.0 1.0 HB1 A:ALA2538 4.1 71.6 1.0 CD2 A:PHE2576 4.3 62.0 1.0 C1 A:T442573 4.3 107.5 1.0 C5 A:T442573 4.3 107.5 1.0 HB2 A:SER2577 4.4 63.0 1.0 HD23 A:LEU2580 4.5 44.1 1.0 HB3 A:ALA2538 4.6 71.6 1.0 HD1 A:PHE2539 4.6 74.6 1.0 O A:ALA2538 4.6 71.6 1.0 C3' A:T442573 4.7 107.5 1.0 CD1 A:PHE2539 4.7 74.6 1.0 CB A:ALA2538 4.8 71.6 1.0 C A:ALA2538 4.8 71.6 1.0 CA A:PHE2539 4.8 74.6 1.0 CZ A:PHE2576 4.8 62.0 1.0 C6' A:T442573 4.8 107.5 1.0 HZ A:PHE2576 4.8 62.0 1.0 HE1 A:PHE2539 4.8 74.6 1.0 CE1 A:PHE2539 4.8 74.6 1.0 C6 A:T442573 4.9 107.5 1.0 O A:VAL2472 4.9 54.3 1.0 HB2 A:SER2534 4.9 77.8 1.0 N A:PHE2539 4.9 74.6 1.0 HB3 A:SER2473 5.0 62.1 1.0

Iodine binding site 2 out of 8 in the Structure of Native, Iodinated Bovine Thyroglobulin Solved on Strepavidin Affinity Grids.


Mono view


Stereo pair view

A full contact list of Iodine with other atoms in the I binding site number 2 of Structure of Native, Iodinated Bovine Thyroglobulin Solved on Strepavidin Affinity Grids. within 5.0Å range: probe atom residue distance (Å) B Occ A:I2573 b:107.5 occ:1.00 I3' A:T442573 0.0 107.5 1.0 C3' A:T442573 2.1 107.5 1.0 C2' A:T442573 3.0 107.5 1.0 C4' A:T442573 3.0 107.5 1.0 HG A:SER2473 3.1 62.1 1.0 HB3 A:SER2473 3.1 62.1 1.0 HA A:SER2534 3.2 77.8 1.0 O4' A:T442573 3.2 107.5 1.0 HB3 A:SER2534 3.6 77.8 1.0 N A:SER2534 3.6 77.8 1.0 OG A:SER2473 3.7 62.1 1.0 CB A:SER2473 3.7 62.1 1.0 H A:SER2534 3.7 77.8 1.0 CA A:SER2534 3.8 77.8 1.0 HA A:THR2533 3.9 72.8 1.0 C A:THR2533 3.9 72.8 1.0 HB2 A:SER2473 3.9 62.1 1.0 CB A:SER2534 4.2 77.8 1.0 O A:THR2533 4.3 72.8 1.0 C1' A:T442573 4.3 107.5 1.0 C5' A:T442573 4.3 107.5 1.0 HB1 A:ALA2538 4.4 71.6 1.0 CA A:THR2533 4.4 72.8 1.0 HB2 A:SER2534 4.6 77.8 1.0 HB2 A:ALA2538 4.7 71.6 1.0 HZ3 A:LYS2524 4.8 55.7 1.0 HZ2 A:LYS2524 4.8 55.7 1.0 C6' A:T442573 4.9 107.5 1.0 CB A:ALA2538 4.9 71.6 1.0

Iodine binding site 3 out of 8 in the Structure of Native, Iodinated Bovine Thyroglobulin Solved on Strepavidin Affinity Grids.


Mono view


Stereo pair view

A full contact list of Iodine with other atoms in the I binding site number 3 of Structure of Native, Iodinated Bovine Thyroglobulin Solved on Strepavidin Affinity Grids. within 5.0Å range: probe atom residue distance (Å) B Occ A:I2573 b:107.5 occ:1.00 I5 A:T442573 0.0 107.5 1.0 C5 A:T442573 2.1 107.5 1.0 HE2 A:LYS2524 3.0 55.7 1.0 C6 A:T442573 3.0 107.5 1.0 C4 A:T442573 3.0 107.5 1.0 HG A:SER2577 3.1 63.0 1.0 O A:ALA677 3.1 61.6 1.0 O4 A:T442573 3.2 107.5 1.0 HD2 A:LYS2524 3.2 55.7 1.0 HZ3 A:LYS2524 3.3 55.7 1.0 HD3 A:LYS2524 3.5 55.7 1.0 HG21 A:ILE2517 3.5 43.1 1.0 CE A:LYS2524 3.6 55.7 1.0 CD A:LYS2524 3.6 55.7 1.0 HB2 A:PRO676 3.7 72.5 1.0 C1' A:T442573 3.7 107.5 1.0 NZ A:LYS2524 3.8 55.7 1.0 OG A:SER2577 3.9 63.0 1.0 HG22 A:ILE2517 4.1 43.1 1.0 CG2 A:ILE2517 4.1 43.1 1.0 C6' A:T442573 4.1 107.5 1.0 HG23 A:ILE2517 4.2 43.1 1.0 HZ1 A:LYS2524 4.2 55.7 1.0 C A:ALA677 4.3 61.6 1.0 C1 A:T442573 4.3 107.5 1.0 C3 A:T442573 4.3 107.5 1.0 C2' A:T442573 4.4 107.5 1.0 HA3 A:GLY678 4.4 58.6 1.0 HB2 A:SER2577 4.4 63.0 1.0 HE3 A:LYS2524 4.4 55.7 1.0 HZ2 A:LYS2524 4.6 55.7 1.0 CB A:PRO676 4.6 72.5 1.0 CB A:SER2577 4.6 63.0 1.0 HB3 A:SER2577 4.7 63.0 1.0 HD13 A:ILE2517 4.7 43.1 1.0 C2 A:T442573 4.9 107.5 1.0 HB3 A:PRO676 4.9 72.5 1.0 HG2 A:PRO676 4.9 72.5 1.0

Iodine binding site 4 out of 8 in the Structure of Native, Iodinated Bovine Thyroglobulin Solved on Strepavidin Affinity Grids.


Mono view


Stereo pair view

A full contact list of Iodine with other atoms in the I binding site number 4 of Structure of Native, Iodinated Bovine Thyroglobulin Solved on Strepavidin Affinity Grids. within 5.0Å range: probe atom residue distance (Å) B Occ A:I2573 b:107.5 occ:1.00 I5' A:T442573 0.0 107.5 1.0 C5' A:T442573 2.1 107.5 1.0 HG12 A:VAL2472 2.9 54.3 1.0 C6' A:T442573 3.0 107.5 1.0 C4' A:T442573 3.0 107.5 1.0 H A:VAL2472 3.0 54.3 1.0 HB2 A:LYS2524 3.2 55.7 1.0 O4' A:T442573 3.2 107.5 1.0 HB1 A:ALA2520 3.3 41.5 1.0 HB3 A:ALA2520 3.4 41.5 1.0 HG11 A:VAL2472 3.6 54.3 1.0 CG1 A:VAL2472 3.7 54.3 1.0 HA A:ALA2471 3.7 49.4 1.0 N A:VAL2472 3.8 54.3 1.0 CB A:ALA2520 3.8 41.5 1.0 O A:ALA2520 3.9 41.5 1.0 HB1 A:ALA2471 4.0 49.4 1.0 HG12 A:VAL2523 4.0 44.1 1.0 CB A:LYS2524 4.0 55.7 1.0 HA A:LYS2524 4.1 55.7 1.0 HB A:VAL2523 4.1 44.1 1.0 H A:LYS2524 4.1 55.7 1.0 HG13 A:VAL2472 4.3 54.3 1.0 N A:LYS2524 4.3 55.7 1.0 C1' A:T442573 4.3 107.5 1.0 C3' A:T442573 4.3 107.5 1.0 HG23 A:ILE2517 4.4 43.1 1.0 CA A:LYS2524 4.4 55.7 1.0 HB3 A:LYS2524 4.4 55.7 1.0 HB2 A:ALA2520 4.4 41.5 1.0 CA A:ALA2471 4.4 49.4 1.0 HD2 A:LYS2524 4.6 55.7 1.0 C A:ALA2471 4.6 49.4 1.0 CB A:ALA2471 4.7 49.4 1.0 CA A:VAL2472 4.7 54.3 1.0 CB A:VAL2472 4.7 54.3 1.0 C A:ALA2520 4.7 41.5 1.0 CG1 A:VAL2523 4.8 44.1 1.0 O A:VAL2472 4.9 54.3 1.0 C2' A:T442573 4.9 107.5 1.0 HA A:ILE2517 4.9 43.1 1.0 HB2 A:ALA2471 4.9 49.4 1.0 CB A:VAL2523 4.9 44.1 1.0 HB A:VAL2472 4.9 54.3 1.0 C A:VAL2472 4.9 54.3 1.0 CA A:ALA2520 5.0 41.5 1.0 HG11 A:VAL2523 5.0 44.1 1.0

Iodine binding site 5 out of 8 in the Structure of Native, Iodinated Bovine Thyroglobulin Solved on Strepavidin Affinity Grids.


Mono view


Stereo pair view

A full contact list of Iodine with other atoms in the I binding site number 5 of Structure of Native, Iodinated Bovine Thyroglobulin Solved on Strepavidin Affinity Grids. within 5.0Å range: probe atom residue distance (Å) B Occ B:I2573 b:107.0 occ:1.00 I3 B:T442573 0.0 107.0 1.0 C3 B:T442573 2.1 107.0 1.0 C2 B:T442573 3.0 107.0 1.0 HE2 B:PHE2576 3.0 56.4 1.0 C4 B:T442573 3.0 107.0 1.0 O4 B:T442573 3.2 107.0 1.0 HB2 B:ALA2542 3.3 52.1 1.0 HB3 B:ALA2542 3.5 52.1 1.0 C2' B:T442573 3.5 107.0 1.0 C1' B:T442573 3.6 107.0 1.0 CB B:ALA2542 3.7 52.1 1.0 HB1 B:ALA2542 3.7 52.1 1.0 HA B:PHE2539 3.8 70.3 1.0 CE2 B:PHE2576 3.9 56.4 1.0 HD2 B:PHE2576 4.0 56.4 1.0 HB1 B:ALA2538 4.1 67.9 1.0 HB2 B:SER2577 4.3 60.4 1.0 C1 B:T442573 4.3 107.0 1.0 C5 B:T442573 4.3 107.0 1.0 CD2 B:PHE2576 4.4 56.4 1.0 O B:ALA2538 4.5 67.9 1.0 C3' B:T442573 4.5 107.0 1.0 CA B:PHE2539 4.7 70.3 1.0 HB2 B:SER2534 4.7 77.0 1.0 HD23 B:LEU2580 4.7 40.6 1.0 HB3 B:ALA2538 4.7 67.9 1.0 C B:ALA2538 4.7 67.9 1.0 CD1 B:PHE2539 4.8 70.3 1.0 C6' B:T442573 4.8 107.0 1.0 CB B:ALA2538 4.8 67.9 1.0 N B:PHE2539 4.8 70.3 1.0 HB3 B:SER2534 4.8 77.0 1.0 CE1 B:PHE2539 4.9 70.3 1.0 C6 B:T442573 4.9 107.0 1.0 CG B:PHE2539 4.9 70.3 1.0 HB3 B:SER2473 4.9 58.7 1.0 CZ B:PHE2576 5.0 56.4 1.0

Iodine binding site 6 out of 8 in the Structure of Native, Iodinated Bovine Thyroglobulin Solved on Strepavidin Affinity Grids.


Mono view


Stereo pair view

A full contact list of Iodine with other atoms in the I binding site number 6 of Structure of Native, Iodinated Bovine Thyroglobulin Solved on Strepavidin Affinity Grids. within 5.0Å range: probe atom residue distance (Å) B Occ B:I2573 b:107.0 occ:1.00 I3' B:T442573 0.0 107.0 1.0 C3' B:T442573 2.1 107.0 1.0 HA B:SER2534 2.9 77.0 1.0 HG B:SER2473 2.9 58.7 1.0 C2' B:T442573 3.0 107.0 1.0 C4' B:T442573 3.0 107.0 1.0 HB3 B:SER2473 3.1 58.7 1.0 O4' B:T442573 3.2 107.0 1.0 N B:SER2534 3.4 77.0 1.0 HB3 B:SER2534 3.5 77.0 1.0 CA B:SER2534 3.5 77.0 1.0 OG B:SER2473 3.6 58.7 1.0 H B:SER2534 3.7 77.0 1.0 C B:THR2533 3.7 71.4 1.0 CB B:SER2473 3.7 58.7 1.0 HB2 B:SER2473 3.8 58.7 1.0 HA B:THR2533 3.9 71.4 1.0 O B:THR2533 3.9 71.4 1.0 HB1 B:ALA2538 4.0 67.9 1.0 CB B:SER2534 4.1 77.0 1.0 HB2 B:ALA2538 4.3 67.9 1.0 C1' B:T442573 4.3 107.0 1.0 C5' B:T442573 4.3 107.0 1.0 CA B:THR2533 4.4 71.4 1.0 HB2 B:SER2534 4.5 77.0 1.0 HZ3 B:LYS2524 4.5 54.6 1.0 CB B:ALA2538 4.6 67.9 1.0 HZ2 B:LYS2524 4.7 54.6 1.0 HB3 B:ALA2538 4.7 67.9 1.0 C6' B:T442573 4.9 107.0 1.0 C B:SER2534 4.9 77.0 1.0 H B:SER2535 4.9 76.9 1.0

Iodine binding site 7 out of 8 in the Structure of Native, Iodinated Bovine Thyroglobulin Solved on Strepavidin Affinity Grids.


Mono view


Stereo pair view

A full contact list of Iodine with other atoms in the I binding site number 7 of Structure of Native, Iodinated Bovine Thyroglobulin Solved on Strepavidin Affinity Grids. within 5.0Å range: probe atom residue distance (Å) B Occ B:I2573 b:107.0 occ:1.00 I5 B:T442573 0.0 107.0 1.0 C5 B:T442573 2.1 107.0 1.0 HG B:SER2577 2.9 60.4 1.0 HE2 B:LYS2524 3.0 54.6 1.0 C6 B:T442573 3.0 107.0 1.0 C4 B:T442573 3.0 107.0 1.0 O B:ALA677 3.1 58.5 1.0 O4 B:T442573 3.2 107.0 1.0 HB2 B:PRO676 3.3 71.2 1.0 HZ3 B:LYS2524 3.6 54.6 1.0 HD2 B:LYS2524 3.7 54.6 1.0 CE B:LYS2524 3.7 54.6 1.0 HD3 B:LYS2524 3.7 54.6 1.0 C1' B:T442573 3.7 107.0 1.0 OG B:SER2577 3.7 60.4 1.0 HG21 B:ILE2517 3.9 39.6 1.0 CD B:LYS2524 3.9 54.6 1.0 NZ B:LYS2524 4.1 54.6 1.0 C6' B:T442573 4.1 107.0 1.0 CB B:PRO676 4.2 71.2 1.0 C1 B:T442573 4.3 107.0 1.0 HZ1 B:LYS2524 4.3 54.6 1.0 C3 B:T442573 4.3 107.0 1.0 C B:ALA677 4.3 58.5 1.0 HB2 B:SER2577 4.4 60.4 1.0 HA3 B:GLY678 4.4 55.3 1.0 HG2 B:PRO676 4.5 71.2 1.0 CB B:SER2577 4.5 60.4 1.0 HB3 B:PRO676 4.5 71.2 1.0 C2' B:T442573 4.5 107.0 1.0 HB3 B:SER2577 4.6 60.4 1.0 HE3 B:LYS2524 4.6 54.6 1.0 HG22 B:ILE2517 4.6 39.6 1.0 CG2 B:ILE2517 4.6 39.6 1.0 CG B:PRO676 4.8 71.2 1.0 HG23 B:ILE2517 4.8 39.6 1.0 C2 B:T442573 4.9 107.0 1.0 HG3 B:PRO676 4.9 71.2 1.0 HZ2 B:LYS2524 4.9 54.6 1.0 C B:PRO676 4.9 71.2 1.0 N B:ALA677 5.0 58.5 1.0

Iodine binding site 8 out of 8 in the Structure of Native, Iodinated Bovine Thyroglobulin Solved on Strepavidin Affinity Grids.


Mono view


Stereo pair view

A full contact list of Iodine with other atoms in the I binding site number 8 of Structure of Native, Iodinated Bovine Thyroglobulin Solved on Strepavidin Affinity Grids. within 5.0Å range: probe atom residue distance (Å) B Occ B:I2573 b:107.0 occ:1.00 I5' B:T442573 0.0 107.0 1.0 C5' B:T442573 2.1 107.0 1.0 HG12 B:VAL2472 3.0 49.5 1.0 HB2 B:LYS2524 3.0 54.6 1.0 C6' B:T442573 3.0 107.0 1.0 C4' B:T442573 3.0 107.0 1.0 O4' B:T442573 3.2 107.0 1.0 H B:VAL2472 3.4 49.5 1.0 HB1 B:ALA2520 3.6 38.2 1.0 HB3 B:ALA2520 3.7 38.2 1.0 CG1 B:VAL2472 3.8 49.5 1.0 HG11 B:VAL2472 3.9 49.5 1.0 CB B:LYS2524 3.9 54.6 1.0 CB B:ALA2520 4.1 38.2 1.0 O B:ALA2520 4.1 38.2 1.0 HG23 B:ILE2517 4.1 39.6 1.0 HA B:LYS2524 4.1 54.6 1.0 N B:VAL2472 4.1 49.5 1.0 HA B:ALA2471 4.2 44.4 1.0 H B:LYS2524 4.2 54.6 1.0 HD2 B:LYS2524 4.2 54.6 1.0 HG13 B:VAL2472 4.3 49.5 1.0 C1' B:T442573 4.3 107.0 1.0 HB3 B:LYS2524 4.3 54.6 1.0 HG12 B:VAL2523 4.3 41.1 1.0 C3' B:T442573 4.3 107.0 1.0 HB B:VAL2523 4.4 41.1 1.0 HB1 B:ALA2471 4.4 44.4 1.0 CA B:LYS2524 4.4 54.6 1.0 N B:LYS2524 4.4 54.6 1.0 HB2 B:ALA2520 4.7 38.2 1.0 O B:VAL2472 4.8 49.5 1.0 CD B:LYS2524 4.8 54.6 1.0 HG22 B:ILE2517 4.9 39.6 1.0 CA B:ALA2471 4.9 44.4 1.0 C2' B:T442573 4.9 107.0 1.0 CG B:LYS2524 4.9 54.6 1.0 CA B:VAL2472 4.9 49.5 1.0 C B:ALA2520 4.9 38.2 1.0 CB B:VAL2472 4.9 49.5 1.0 CG2 B:ILE2517 4.9 39.6 1.0 C B:VAL2472 4.9 49.5 1.0 HA B:ILE2517 4.9 39.6 1.0 HD3 B:LYS2524 4.9 54.6 1.0 C B:ALA2471 5.0 44.4 1.0

N.Marechal, B.P.Serrano, X.Zhang, C.J.Weitz. Formation of Thyroid Hormone Revealed By A Cryo-Em Structure of Native Bovine Thyroglobulin. Nat Commun V. 13 2380 2022.
ISSN: ESSN 2041-1723
PubMed: 35501346
DOI: 10.1038/S41467-022-30082-4