Iodine in PDB 7r4d: Bovine Complex I in the Presence of IM1761092, Deactive Class VI (Composite Map)

All present enzymatic activity of Bovine Complex I in the Presence of IM1761092, Deactive Class VI (Composite Map):
1.6.5.3; 1.6.99.3; 7.1.1.2;

The structure of Bovine Complex I in the Presence of IM1761092, Deactive Class VI (Composite Map) also contains other interesting chemical elements:

Potassium	(K)	1 atom
Magnesium	(Mg)	1 atom
Zinc	(Zn)	1 atom
Iron	(Fe)	28 atoms
Chlorine	(Cl)	1 atom

The binding sites of Iodine atom in the Bovine Complex I in the Presence of IM1761092, Deactive Class VI (Composite Map) (pdb code 7r4d). This binding sites where shown within 5.0 Angstroms radius around Iodine atom.
In total only one binding site of Iodine was determined in the Bovine Complex I in the Presence of IM1761092, Deactive Class VI (Composite Map), PDB code: 7r4d:

Iodine binding site 1 out of 1 in the Bovine Complex I in the Presence of IM1761092, Deactive Class VI (Composite Map)


Mono view


Stereo pair view

A full contact list of Iodine with other atoms in the I binding site number 1 of Bovine Complex I in the Presence of IM1761092, Deactive Class VI (Composite Map) within 5.0Å range: probe atom residue distance (Å) B Occ N:I503 b:33.8 occ:1.00 I02 N:I49503 0.0 33.8 1.0 C13 N:I49503 2.1 33.8 1.0 C11 N:I49503 3.0 33.8 1.0 C12 N:I49503 3.0 33.8 1.0 O d:MET82 3.3 22.4 1.0 CL01 N:I49503 3.3 33.8 1.0 C d:MET82 3.8 22.4 1.0 CD1 d:TYR83 3.9 20.9 1.0 CB d:ARG86 3.9 22.6 1.0 CG N:GLU347 4.0 24.9 1.0 CB N:SER344 4.0 21.3 1.0 CE1 d:TYR83 4.0 20.9 1.0 CB d:MET82 4.2 22.4 1.0 N d:TYR83 4.2 20.9 1.0 CA d:TYR83 4.3 20.9 1.0 C09 N:I49503 4.3 33.8 1.0 C10 N:I49503 4.4 33.8 1.0 CD d:ARG86 4.4 22.6 1.0 CD N:GLU347 4.5 24.9 1.0 CB N:GLU347 4.5 24.9 1.0 CG d:ARG86 4.6 22.6 1.0 CA d:MET82 4.6 22.4 1.0 CG d:TYR83 4.6 20.9 1.0 CA N:SER344 4.8 21.3 1.0 C07 N:I49503 4.9 33.8 1.0 CZ d:TYR83 4.9 20.9 1.0 NE d:ARG86 4.9 22.6 1.0 OE2 N:GLU347 5.0 24.9 1.0 OE1 N:GLU347 5.0 24.9 1.0 O N:SER344 5.0 21.3 1.0

H.R.Bridges, J.N.Blaza, Z.Yin, I.Chung, M.N.Pollak, J.Hirst. Structural Basis of Mammalian Respiratory Complex I Inhibition By Medicinal Biguanides. Science V. 379 351 2023.
ISSN: ESSN 1095-9203
PubMed: 36701435
DOI: 10.1126/SCIENCE.ADE3332