Iodine »
PDB 7se5-7z76 »
7z76 »
Iodine in PDB 7z76: Crystal Structure of Compound 10 in Complex with the Bromodomain of Human SMARCA2 and Pvhl:Elonginc:Elonginb
Protein crystallography data
The structure of Crystal Structure of Compound 10 in Complex with the Bromodomain of Human SMARCA2 and Pvhl:Elonginc:Elonginb, PDB code: 7z76
was solved by
G.Bader,
J.Boettcher,
B.Wolkerstorfer,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 33.96 / 1.32 |
| Space group | P 1 21 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 47.469, 101.395, 69.131, 90, 105.56, 90 |
| R / Rfree (%) | 17.8 / 20.2 |
Other elements in 7z76:
The structure of Crystal Structure of Compound 10 in Complex with the Bromodomain of Human SMARCA2 and Pvhl:Elonginc:Elonginb also contains other interesting chemical elements:
| Bromine | (Br) | 1 atom |
Iodine Binding Sites:
The binding sites of Iodine atom in the Crystal Structure of Compound 10 in Complex with the Bromodomain of Human SMARCA2 and Pvhl:Elonginc:Elonginb
(pdb code 7z76). This binding sites where shown within
5.0 Angstroms radius around Iodine atom.
In total 7 binding sites of Iodine where determined in the Crystal Structure of Compound 10 in Complex with the Bromodomain of Human SMARCA2 and Pvhl:Elonginc:Elonginb, PDB code: 7z76:
Jump to Iodine binding site number: 1; 2; 3; 4; 5; 6; 7;
In total 7 binding sites of Iodine where determined in the Crystal Structure of Compound 10 in Complex with the Bromodomain of Human SMARCA2 and Pvhl:Elonginc:Elonginb, PDB code: 7z76:
Jump to Iodine binding site number: 1; 2; 3; 4; 5; 6; 7;
Iodine binding site 1 out of 7 in 7z76
Go back to
Iodine Binding Sites List in 7z76
Iodine binding site 1 out
of 7 in the Crystal Structure of Compound 10 in Complex with the Bromodomain of Human SMARCA2 and Pvhl:Elonginc:Elonginb
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Iodine with other atoms in the I binding
site number 1 of Crystal Structure of Compound 10 in Complex with the Bromodomain of Human SMARCA2 and Pvhl:Elonginc:Elonginb within 5.0Å range:
|
Iodine binding site 2 out of 7 in 7z76
Go back to
Iodine Binding Sites List in 7z76
Iodine binding site 2 out
of 7 in the Crystal Structure of Compound 10 in Complex with the Bromodomain of Human SMARCA2 and Pvhl:Elonginc:Elonginb
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Iodine with other atoms in the I binding
site number 2 of Crystal Structure of Compound 10 in Complex with the Bromodomain of Human SMARCA2 and Pvhl:Elonginc:Elonginb within 5.0Å range:
|
Iodine binding site 3 out of 7 in 7z76
Go back to
Iodine Binding Sites List in 7z76
Iodine binding site 3 out
of 7 in the Crystal Structure of Compound 10 in Complex with the Bromodomain of Human SMARCA2 and Pvhl:Elonginc:Elonginb
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Iodine with other atoms in the I binding
site number 3 of Crystal Structure of Compound 10 in Complex with the Bromodomain of Human SMARCA2 and Pvhl:Elonginc:Elonginb within 5.0Å range:
|
Iodine binding site 4 out of 7 in 7z76
Go back to
Iodine Binding Sites List in 7z76
Iodine binding site 4 out
of 7 in the Crystal Structure of Compound 10 in Complex with the Bromodomain of Human SMARCA2 and Pvhl:Elonginc:Elonginb
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Iodine with other atoms in the I binding
site number 4 of Crystal Structure of Compound 10 in Complex with the Bromodomain of Human SMARCA2 and Pvhl:Elonginc:Elonginb within 5.0Å range:
|
Iodine binding site 5 out of 7 in 7z76
Go back to
Iodine Binding Sites List in 7z76
Iodine binding site 5 out
of 7 in the Crystal Structure of Compound 10 in Complex with the Bromodomain of Human SMARCA2 and Pvhl:Elonginc:Elonginb
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Iodine with other atoms in the I binding
site number 5 of Crystal Structure of Compound 10 in Complex with the Bromodomain of Human SMARCA2 and Pvhl:Elonginc:Elonginb within 5.0Å range:
|
Iodine binding site 6 out of 7 in 7z76
Go back to
Iodine Binding Sites List in 7z76
Iodine binding site 6 out
of 7 in the Crystal Structure of Compound 10 in Complex with the Bromodomain of Human SMARCA2 and Pvhl:Elonginc:Elonginb
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Iodine with other atoms in the I binding
site number 6 of Crystal Structure of Compound 10 in Complex with the Bromodomain of Human SMARCA2 and Pvhl:Elonginc:Elonginb within 5.0Å range:
|
Iodine binding site 7 out of 7 in 7z76
Go back to
Iodine Binding Sites List in 7z76
Iodine binding site 7 out
of 7 in the Crystal Structure of Compound 10 in Complex with the Bromodomain of Human SMARCA2 and Pvhl:Elonginc:Elonginb
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Iodine with other atoms in the I binding
site number 7 of Crystal Structure of Compound 10 in Complex with the Bromodomain of Human SMARCA2 and Pvhl:Elonginc:Elonginb within 5.0Å range:
|
Reference:
C.Kofink,
N.Trainor,
B.Mair,
S.Wohrle,
M.Wurm,
N.Mischerikow,
M.J.Roy,
G.Bader,
P.Greb,
G.Garavel,
E.Diers,
R.Mclennan,
C.Whitworth,
V.Vetma,
K.Rumpel,
M.Scharnweber,
J.E.Fuchs,
T.Gerstberger,
Y.Cui,
G.Gremel,
P.Chetta,
S.Hopf,
N.Budano,
J.Rinnenthal,
G.Gmaschitz,
M.Mayer,
M.Koegl,
A.Ciulli,
H.Weinstabl,
W.Farnaby.
A Selective and Orally Bioavailable Vhl-Recruiting Protac Achieves SMARCA2 Degradation in Vivo. Nat Commun V. 13 5969 2022.
ISSN: ESSN 2041-1723
PubMed: 36216795
DOI: 10.1038/S41467-022-33430-6
Page generated: Mon Aug 12 02:23:35 2024
ISSN: ESSN 2041-1723
PubMed: 36216795
DOI: 10.1038/S41467-022-33430-6
Last articles
Zn in 9J0NZn in 9J0O
Zn in 9J0P
Zn in 9FJX
Zn in 9EKB
Zn in 9C0F
Zn in 9CAH
Zn in 9CH0
Zn in 9CH3
Zn in 9CH1
