Iodine in PDB 8bw9: Cryo-Em Structure of the Raf Activating Complex Ksr-Mek-Cnk-Hyp

All present enzymatic activity of Cryo-Em Structure of the Raf Activating Complex Ksr-Mek-Cnk-Hyp:
2.7.12.2;

The structure of Cryo-Em Structure of the Raf Activating Complex Ksr-Mek-Cnk-Hyp also contains other interesting chemical elements:

Magnesium	(Mg)	1 atom
Fluorine	(F)	1 atom

The binding sites of Iodine atom in the Cryo-Em Structure of the Raf Activating Complex Ksr-Mek-Cnk-Hyp (pdb code 8bw9). This binding sites where shown within 5.0 Angstroms radius around Iodine atom.
In total only one binding site of Iodine was determined in the Cryo-Em Structure of the Raf Activating Complex Ksr-Mek-Cnk-Hyp, PDB code: 8bw9:

Iodine binding site 1 out of 1 in the Cryo-Em Structure of the Raf Activating Complex Ksr-Mek-Cnk-Hyp


Mono view


Stereo pair view

A full contact list of Iodine with other atoms in the I binding site number 1 of Cryo-Em Structure of the Raf Activating Complex Ksr-Mek-Cnk-Hyp within 5.0Å range: probe atom residue distance (Å) B Occ C:I402 b:190.8 occ:1.00 I17 C:QOM402 0.0 190.8 1.0 C14 C:QOM402 2.1 146.3 1.0 C13 C:QOM402 3.0 141.9 1.0 C15 C:QOM402 3.0 145.4 1.0 CG2 C:VAL146 3.7 90.4 1.0 N C:ASP227 4.1 104.6 1.0 SD C:MET162 4.1 126.2 1.0 CB C:CYS226 4.2 88.5 1.0 C12 C:QOM402 4.3 145.3 1.0 C16 C:QOM402 4.3 138.7 1.0 CA C:CYS226 4.4 80.8 1.0 CE2 C:PHE228 4.5 99.7 1.0 CD1 C:LEU137 4.6 148.0 1.0 OD1 C:ASP227 4.7 114.5 1.0 CB C:MET162 4.7 135.6 1.0 CD2 C:LEU137 4.7 143.5 1.0 C C:CYS226 4.8 90.7 1.0 CG C:LEU137 4.8 146.3 1.0 C11 C:QOM402 4.9 141.9 1.0 O C:VAL146 4.9 102.0 1.0 CA C:ASP227 5.0 106.5 1.0 CZ C:PHE228 5.0 100.7 1.0

P.Maisonneuve, S.Malha, F.Bergeron-Labrecque, M.Lefrancois, X.I.Ma, G.Arseneault, R.Fronzes, I.Kurinov, F.Sicheri, M.Therrien. The Cnk-Hyp Scaffolding Complex Promotes Raf Activation By Enhancing Ksr-Mek Interaction To Be Published 2024.
DOI: 10.1038/S41594-024-01233-6