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Iodine in PDB 8cxw: Cama Adenine Methyltransferase Complexed to Cognate Substrate Dna and Inhibitor MC4682 (Compound 164)Enzymatic activity of Cama Adenine Methyltransferase Complexed to Cognate Substrate Dna and Inhibitor MC4682 (Compound 164)
All present enzymatic activity of Cama Adenine Methyltransferase Complexed to Cognate Substrate Dna and Inhibitor MC4682 (Compound 164):
2.1.1.72; Protein crystallography data
The structure of Cama Adenine Methyltransferase Complexed to Cognate Substrate Dna and Inhibitor MC4682 (Compound 164), PDB code: 8cxw
was solved by
J.R.Horton,
J.Zhou,
X.Cheng,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 8cxw:
The structure of Cama Adenine Methyltransferase Complexed to Cognate Substrate Dna and Inhibitor MC4682 (Compound 164) also contains other interesting chemical elements:
Iodine Binding Sites:
The binding sites of Iodine atom in the Cama Adenine Methyltransferase Complexed to Cognate Substrate Dna and Inhibitor MC4682 (Compound 164)
(pdb code 8cxw). This binding sites where shown within
5.0 Angstroms radius around Iodine atom.
In total 3 binding sites of Iodine where determined in the Cama Adenine Methyltransferase Complexed to Cognate Substrate Dna and Inhibitor MC4682 (Compound 164), PDB code: 8cxw: Jump to Iodine binding site number: 1; 2; 3; Iodine binding site 1 out of 3 in 8cxwGo back to Iodine Binding Sites List in 8cxw
Iodine binding site 1 out
of 3 in the Cama Adenine Methyltransferase Complexed to Cognate Substrate Dna and Inhibitor MC4682 (Compound 164)
Mono view Stereo pair view
Iodine binding site 2 out of 3 in 8cxwGo back to Iodine Binding Sites List in 8cxw
Iodine binding site 2 out
of 3 in the Cama Adenine Methyltransferase Complexed to Cognate Substrate Dna and Inhibitor MC4682 (Compound 164)
Mono view Stereo pair view
Iodine binding site 3 out of 3 in 8cxwGo back to Iodine Binding Sites List in 8cxw
Iodine binding site 3 out
of 3 in the Cama Adenine Methyltransferase Complexed to Cognate Substrate Dna and Inhibitor MC4682 (Compound 164)
Mono view Stereo pair view
Reference:
J.Zhou,
J.R.Horton,
M.Menna,
F.Fiorentino,
R.Ren,
D.Yu,
T.Hajian,
M.Vedadi,
G.Mazzoccanti,
A.Ciogli,
E.Weinhold,
M.Huben,
R.M.Blumenthal,
X.Zhang,
A.Mai,
D.Rotili,
X.Cheng.
Systematic Design of Adenosine Analogs As Inhibitors of A Clostridioides Difficile- Specific Dna Adenine Methyltransferase Required For Normal Sporulation and Persistence. J.Med.Chem. 2022.
Page generated: Wed Apr 5 09:27:03 2023
ISSN: ISSN 0022-2623 PubMed: 36581322 DOI: 10.1021/ACS.JMEDCHEM.2C01789 |
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