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Iodine in PDB 7m0x: Crystal Structure of the Braf:MEK1 Kinases in Complex with Amppnp and PD0325901

Enzymatic activity of Crystal Structure of the Braf:MEK1 Kinases in Complex with Amppnp and PD0325901

All present enzymatic activity of Crystal Structure of the Braf:MEK1 Kinases in Complex with Amppnp and PD0325901:
2.7.11.1; 2.7.12.2;

Protein crystallography data

The structure of Crystal Structure of the Braf:MEK1 Kinases in Complex with Amppnp and PD0325901, PDB code: 7m0x was solved by K.Li, G.Gonzalez Del-Pino, B.H.Ha, E.Park, M.J.Eck, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 43.57 / 2.47
Space group P 31 2 1
Cell size a, b, c (Å), α, β, γ (°) 116.527, 116.527, 130.712, 90, 90, 120
R / Rfree (%) 17.8 / 21.5

Other elements in 7m0x:

The structure of Crystal Structure of the Braf:MEK1 Kinases in Complex with Amppnp and PD0325901 also contains other interesting chemical elements:

Magnesium (Mg) 2 atoms
Fluorine (F) 3 atoms
Chlorine (Cl) 1 atom

Iodine Binding Sites:

The binding sites of Iodine atom in the Crystal Structure of the Braf:MEK1 Kinases in Complex with Amppnp and PD0325901 (pdb code 7m0x). This binding sites where shown within 5.0 Angstroms radius around Iodine atom.
In total only one binding site of Iodine was determined in the Crystal Structure of the Braf:MEK1 Kinases in Complex with Amppnp and PD0325901, PDB code: 7m0x:

Iodine binding site 1 out of 1 in 7m0x

Go back to Iodine Binding Sites List in 7m0x
Iodine binding site 1 out of 1 in the Crystal Structure of the Braf:MEK1 Kinases in Complex with Amppnp and PD0325901


Mono view


Stereo pair view

A full contact list of Iodine with other atoms in the I binding site number 1 of Crystal Structure of the Braf:MEK1 Kinases in Complex with Amppnp and PD0325901 within 5.0Å range:
probe atom residue distance (Å) B Occ
B:I803

b:45.5
occ:1.00
 I23 B:4BM803 0.0 45.5 1.0
C04 B:4BM803 2.1 38.6 1.0
C05 B:4BM803 3.0 36.1 1.0
C03 B:4BM803 3.1 34.1 1.0
O B:VAL127 3.2 38.0 1.0
SG B:CYS207 3.8 34.7 0.2
CB B:VAL127 4.0 45.5 1.0
C B:VAL127 4.1 38.8 1.0
CE1 B:PHE209 4.1 34.8 1.0
CG1 B:VAL127 4.2 40.0 1.0
CZ B:PHE209 4.2 33.1 1.0
O B:GLY128 4.3 42.0 1.0
C06 B:4BM803 4.3 38.8 1.0
C02 B:4BM803 4.4 36.4 1.0
CA B:VAL127 4.5 41.5 1.0
CB B:CYS207 4.6 36.3 0.8
CD2 B:LEU118 4.7 31.8 1.0
CA B:CYS207 4.7 35.7 0.8
CB B:PHE129 4.7 38.4 1.0
CA B:CYS207 4.7 34.9 0.2
CD1 B:LEU118 4.7 31.4 1.0
SD B:MET143 4.8 45.4 1.0
CB B:MET143 4.8 41.2 1.0
C B:GLY128 4.8 43.7 1.0
CG2 B:ILE126 4.8 35.5 1.0
CB B:CYS207 4.8 36.5 0.2
N B:VAL127 4.9 37.8 1.0
C01 B:4BM803 4.9 34.3 1.0
N B:ASP208 4.9 35.7 1.0
O B:LEU206 5.0 38.4 1.0

Reference:

K.Li, G.Gonzalez Del-Pino, B.H.Ha, E.Park, M.J.Eck. Crystal Structure of the Braf:MEK1 Kinases in Complex with Amppnp and PD0325901 To Be Published.
Page generated: Mon Aug 12 01:44:33 2024

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